@article{52545ad6646b433faf2c42f3ca3e4cfc,
title = "Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia",
abstract = "In vitro prednisolone resistance is a poor prognostic factor in the treatment of childhood acute lymphoblastic leukemia (ALL). In a cohort of 54 children with ALL, a lower expression of the glucocorticoid receptor (GR), but not the relative expression levels of the GR-alpha, GR-beta and GR-P isoforms, was associated with in vitro prednisolone resistance.",
keywords = "Child, Cohort Studies, Drug Resistance, Neoplasm/genetics, Gene Expression Regulation/drug effects, Glucocorticoids/biosynthesis, Humans, Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy, Prednisolone/therapeutic use, Protein Isoforms/biosynthesis, Receptors, Glucocorticoid/biosynthesis",
author = "Tissing, {Wim J E} and Melchior Lauten and Meijerink, {Jules P P} and {den Boer}, {Monique L} and Koper, {Jan Willem} and Peter Sonneveld and Rob Pieters",
year = "2005",
month = sep,
language = "English",
volume = "90",
pages = "1279--81",
journal = "Haematologica",
issn = "0390-6078",
publisher = "Ferrata Storti Foundation",
number = "9",
}