@article{24c9ab1b8cb24c93a2e4a645749d4ad5,
title = "Extended longevity mechanisms in short-lived progeroid mice: Identification of a preservative stress response associated with successful aging",
abstract = "Semantic distinctions between {"}normal{"} aging, {"}pathological{"} aging (or age-related disease) and {"}premature{"} aging (otherwise known as segmental progeria) potentially confound important insights into the nature of each of the complex processes. Here we review a recent, unexpected discovery: the presence of longevity-associated characteristics typical of long-lived endocrine-mutant and dietary-restricted animals in short-lived progeroid mice. These data suggest that a subset of symptoms observed in premature aging, and possibly normal aging as well, may be indirect manifestations of a beneficial adaptive stress response to endogenous oxidative damage, rather than a detrimental result of the damage itself.",
keywords = "Adaptive stress response, Ageing, Base excision repair, DNA damage, Nucleotide excision repair, Progeria, SIRT6",
author = "\{van de Ven\}, Marieke and Andressoo, \{Jaan Olle\} and Holcomb, \{Valerie B.\} and Paul Hasty and Yousin Suh and \{van Steeg\}, Harry and Garinis, \{George A.\} and Hoeijmakers, \{Jan H.J.\} and Mitchell, \{James R.\}",
note = "Funding Information: The authors would like to thank Joris Pothof, David Lombard and Raul Mostoslavsky for informative discussions and critical reading of the manuscript. This work was supported in part by the following grants: National Institutes of Health (1PO1 AG17242-02), Association of International Cancer Research Grant Award (05-280), and Netherlands Organization for Health Research and Development, Research Institute for Diseases in the Elderly (60-60400-98-004).",
year = "2007",
month = jan,
doi = "10.1016/j.mad.2006.11.011",
language = "English",
volume = "128",
pages = "58--63",
journal = "Mechanisms of Ageing and Development",
issn = "0047-6374",
publisher = "Elsevier Ireland Ltd",
number = "1",
}