Failure of posaconazole therapy in a renal transplant patient with invasive aspergillosis due to Aspergillus fumigatus with attenuated susceptibility to posaconazole

Saskia Kuipers, Roger J.M. Brüggemann, Ruud G.L. De Sévaux, John P.F.A. Heesakkers, Willem J.G. Melchers, Johan W. Mouton, Paul E. Verweij

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

33 Citaten (Scopus)

Samenvatting

We report the case of a kidney transplant recipient with invasive aspergillosis due to Aspergillus fumigatus resistant to voriconazole and intermediately susceptible to posaconazole who failed posaconazole therapy. Plasma posaconazole concentrations indicated an unfavorable ratio of the area under the concentration-time curve over the MIC. Posaconazole should be used with caution for invasive aspergillosis caused by strains with attenuated posaconazole susceptibility, as drug exposure may be inadequate, resulting in therapeutic failure.

Originele taal-2Engels
Pagina's (van-tot)3564-3566
Aantal pagina's3
TijdschriftAntimicrobial Agents and Chemotherapy
Volume55
Nummer van het tijdschrift7
DOI's
StatusGepubliceerd - jul. 2011
Extern gepubliceerdJa

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