TY - JOUR
T1 - Failure of posaconazole therapy in a renal transplant patient with invasive aspergillosis due to Aspergillus fumigatus with attenuated susceptibility to posaconazole
AU - Kuipers, Saskia
AU - Brüggemann, Roger J.M.
AU - De Sévaux, Ruud G.L.
AU - Heesakkers, John P.F.A.
AU - Melchers, Willem J.G.
AU - Mouton, Johan W.
AU - Verweij, Paul E.
PY - 2011/7
Y1 - 2011/7
N2 - We report the case of a kidney transplant recipient with invasive aspergillosis due to Aspergillus fumigatus resistant to voriconazole and intermediately susceptible to posaconazole who failed posaconazole therapy. Plasma posaconazole concentrations indicated an unfavorable ratio of the area under the concentration-time curve over the MIC. Posaconazole should be used with caution for invasive aspergillosis caused by strains with attenuated posaconazole susceptibility, as drug exposure may be inadequate, resulting in therapeutic failure.
AB - We report the case of a kidney transplant recipient with invasive aspergillosis due to Aspergillus fumigatus resistant to voriconazole and intermediately susceptible to posaconazole who failed posaconazole therapy. Plasma posaconazole concentrations indicated an unfavorable ratio of the area under the concentration-time curve over the MIC. Posaconazole should be used with caution for invasive aspergillosis caused by strains with attenuated posaconazole susceptibility, as drug exposure may be inadequate, resulting in therapeutic failure.
UR - http://www.scopus.com/inward/record.url?scp=79959189139&partnerID=8YFLogxK
U2 - 10.1128/AAC.01544-10
DO - 10.1128/AAC.01544-10
M3 - Article
C2 - 21502625
AN - SCOPUS:79959189139
SN - 0066-4804
VL - 55
SP - 3564
EP - 3566
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 7
ER -