TY - JOUR
T1 - Favorable outcome of neonatal cerebrospinal fluid shunt-associated Candida meningitis with caspofungin
AU - Jans, Jop
AU - Brüggemann, Roger J.M.
AU - Christdmann, V.
AU - Verweij, Paul E.
AU - Warris, Adilia
PY - 2013/5
Y1 - 2013/5
N2 - Invasive Candida infections associated with medical devices are very difficult to cure without device removal. We present a case of neonatal cerebrospinal fluid shunt-associated Candida meningitis, in which removal of the device was precluded, that was successfully treated with caspofungin. Pharmacokinetic assessment of caspofungin concentrations in cerebrospinal fluid showed that exposure was adequate in the presence of a high systemic exposure. In complex cases of neonatal Candida infections involving medical devices, the addition of caspofungin might be beneficial.
AB - Invasive Candida infections associated with medical devices are very difficult to cure without device removal. We present a case of neonatal cerebrospinal fluid shunt-associated Candida meningitis, in which removal of the device was precluded, that was successfully treated with caspofungin. Pharmacokinetic assessment of caspofungin concentrations in cerebrospinal fluid showed that exposure was adequate in the presence of a high systemic exposure. In complex cases of neonatal Candida infections involving medical devices, the addition of caspofungin might be beneficial.
UR - http://www.scopus.com/inward/record.url?scp=84876232679&partnerID=8YFLogxK
U2 - 10.1128/AAC.02085-12
DO - 10.1128/AAC.02085-12
M3 - Article
C2 - 23439643
AN - SCOPUS:84876232679
SN - 0066-4804
VL - 57
SP - 2391
EP - 2393
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 5
ER -