FDG PET/CT in differentiated thyroid cancer patients with low thyroglobulin levels

Chantal A. Lebbink, Lisa H. de Vries, Inne H.M. Borel Rinkes, Arthur J.A.T. Braat, Rachel S. van Leeuwaarde, Lutske Lodewijk, Mark J.C. van Treijen, Menno R. Vriens, Gerlof D. Valk, Hanneke M. van Santen, Bart de Keizer

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1 Citaat (Scopus)

Samenvatting

Objective: To evaluate the usefulness of [18F]fluorodeoxyglucose (FDG) positron emissive tomography (PET)/CT in patients with low detectable thyroglobulin levels suspicious for persistent or recurrent differentiated thyroid cancer (DTC). Methods: A retrospective case series study evaluating FDG PET/CT in patients with detectable thyroglobulin (Tg) levels (≥0.20 and <10.00 ng/mL) after initial treatment with total thyroidectomy and I-131 thyroid remnant ablation for pT1-3aN0-1bM0 DTC. Sensitivity, specificity, positive (PPV) and negative predictive value (NPV) of FDG PET/CT were calculated. Results: Twenty-seven patients underwent FDG PET/CT. Median Tg level at FDG PET/CT was 2.00 ng/mL (range 0.30-9.00). FDG PET/CT was positive in 14 patients (51.9%): lesions suspicious for lymph node metastases were depicted in 12 patients, and lung metastases in 2. DTC was confirmed in 13/14 FDG PET/CT-positive patients. In 9/13 patients with a negative FDG PET/CT, DTC was confirmed ≤3 months after FDG PET/CT. The sensitivity, PPV, specificity and NPV were 59.1, 92.9, 80.0 and 30.8%, respectively. Conclusions: This case series shows that FDG PET/CT might be useful to detect persistent or recurrent DTC in patients with low detectable Tg. However, when FDG PET/CT is negative, this does not rule out DTC and further investigations are necessary.

Originele taal-2Engels
Pagina's (van-tot)101-110
Aantal pagina's10
TijdschriftEuropean Journal of Endocrinology
Volume187
Nummer van het tijdschrift1
DOI's
StatusGepubliceerd - 24 mei 2022

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