@article{b5d242a4fe9a4477bcdfd8f4751010e4,
title = "Fibronectin is a hypoxia-independent target of the tumor suppressor VHL",
abstract = "The von Hippel-Lindau (VHL) tumor suppressor gene regulates the extracellular matrix by controlling fibronectin deposition. To identify novel VHL target genes, we subjected mRNA from VHL-deficient RCC cells (786-0-pRC) and a transfectant re-expressing wildtype VHL (786-0-VHL) to differential expression profiling. Among the differentially expressed genes, we detected that fibronectin is upregulated in the presence of VHL, while it is not affected by hypoxia. Thus regulation of fibronectin deposition by VHL occurs at the transcriptional level, irrespective of oxygen levels.",
keywords = "Fibronectin, Hypoxia, Microarray, Renal cell carcinoma, VHL",
author = "Bluyssen, {Hans A.R.} and Lolkema, {Martijn P.J.K.} and {Van Beest}, Moniek and Michelle Boone and Snijckers, {Cristel M.J.T.} and Maartje Los and Gebbink, {Martijn F.B.G.} and Branko Braam and Holstege, {Frank C.P.} and Giles, {Rachel H.} and Voest, {Emile E.}",
note = "Funding Information: We thank Maarten Pennings for performing the fibronectin ELISAs and Germa Tooten for IGFBP3 quantifications. This study was supported in part by the Dutch Cancer Society (Grants UU 1999-1879 and UU 1999-2114 to E.V.) and in part by the Dutch Scientific Counsel (NWO) (Grant 920-03-179 to M.L. and E.V.).",
year = "2004",
month = jan,
day = "2",
doi = "10.1016/S0014-5793(03)01392-9",
language = "English",
volume = "556",
pages = "137--142",
journal = "FEBS Letters",
issn = "0014-5793",
number = "1-3",
}