@article{44da53a58f3547cfa3f886e6887f68b8,
title = "Fixed dosing of liposomal amphotericin b in morbidly obese individuals",
abstract = "In this prospective study, we examined the pharmacokinetics of 1 and 2 mg/kg liposomal amphotericin B in 16 morbidly obese individuals (104-177 kg). Body size had no effect on clearance. We recommend a fixed dose in patients ≥100 kg (ie, 300 or 500 mg rather than the current dose of 3 and 5 mg/kg, respectively).",
keywords = "Fungal infection, Fungal treatment, Obese, Optimal dosing, Population pharmacokinetics",
author = "Wasmann, {Roeland E.} and Cornelis Smit and {van Dongen}, {Eric P.H.} and Wiezer, {Ren{\'e} M.J.} and Jill Adler-Moore and {de Beer}, {Yvo M.} and Burger, {David M.} and Knibbe, {Catherijne A.J.} and Br{\"u}ggemann, {Roger J.M.}",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact
[email protected]",
year = "2020",
month = may,
day = "6",
doi = "10.1093/cid/ciz885",
language = "English",
volume = "70",
pages = "2213--2215",
journal = "Clinical infectious diseases : an official publication of the Infectious Diseases Society of America",
issn = "1537-6591",
publisher = "Oxford University Press",
number = "10",
}