Folates and antifolates in the treatment of cancer; role of folic acid supplementation on efficacy of folate and non-folate drugs

G. J. Peters; J. H. Hooijberg; G. J.L. Kaspers; G. Jansen

doi:10.1016/j.tifs.2005.03.008

Folates and antifolates in the treatment of cancer; role of folic acid supplementation on efficacy of folate and non-folate drugs

G. J. Peters, J. H. Hooijberg, G. J.L. Kaspers, G. Jansen

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

10 Citaten (Scopus)

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Folates are essential nutrients for the cell for DNA synthesis. From a nutritional perspective, a high folate status may have a beneficial/protective effect against cancer, birth defects and age-related diseases. However, data presented in this study provide evidence that a high folate status can also have a differential impact on the therapeutic efficacy of both folate-based and other widely used anticancer agents. This study describes the molecular mechanisms underlying these effects, which involve folate influx/efflux proteins, intracellular metabolism and target enzymes.

Originele taal-2	Engels
Pagina's (van-tot)	289-297
Aantal pagina's	9
Tijdschrift	Trends in Food Science and Technology
Volume	16
Nummer van het tijdschrift	6-7
DOI's	https://doi.org/10.1016/j.tifs.2005.03.008
Status	Gepubliceerd - 2005
Extern gepubliceerd	Ja

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abstract = "Folates are essential nutrients for the cell for DNA synthesis. From a nutritional perspective, a high folate status may have a beneficial/protective effect against cancer, birth defects and age-related diseases. However, data presented in this study provide evidence that a high folate status can also have a differential impact on the therapeutic efficacy of both folate-based and other widely used anticancer agents. This study describes the molecular mechanisms underlying these effects, which involve folate influx/efflux proteins, intracellular metabolism and target enzymes.",

author = "Peters, {G. J.} and Hooijberg, {J. H.} and Kaspers, {G. J.L.} and G. Jansen",

note = "Funding Information: Research from the authors was supported by several grants for the Dutch Cancer Society. We also thank Mrs S. van Geloven for secretarial assistance.",

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AU - Peters, G. J.

AU - Hooijberg, J. H.

AU - Kaspers, G. J.L.

AU - Jansen, G.

N1 - Funding Information: Research from the authors was supported by several grants for the Dutch Cancer Society. We also thank Mrs S. van Geloven for secretarial assistance.

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AB - Folates are essential nutrients for the cell for DNA synthesis. From a nutritional perspective, a high folate status may have a beneficial/protective effect against cancer, birth defects and age-related diseases. However, data presented in this study provide evidence that a high folate status can also have a differential impact on the therapeutic efficacy of both folate-based and other widely used anticancer agents. This study describes the molecular mechanisms underlying these effects, which involve folate influx/efflux proteins, intracellular metabolism and target enzymes.

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Folates and antifolates in the treatment of cancer; role of folic acid supplementation on efficacy of folate and non-folate drugs

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