Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

Nai Yang Fu; Bhupinder Pal; Yunshun Chen; Felicity C. Jackling; Michael Milevskiy; François Vaillant; Bianca D. Capaldo; Fusheng Guo; Kevin H. Liu; Anne C. Rios; Nicholas Lim; Andrew J. Kueh; David M. Virshup; Marco J. Herold; Haley O. Tucker; Gordon K. Smyth; Geoffrey J. Lindeman; Jane E. Visvader

doi:10.1016/j.devcel.2018.10.001

Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

Nai Yang Fu
, Bhupinder Pal
, Yunshun Chen
, Felicity C. Jackling
, Michael Milevskiy
, François Vaillant
, Bianca D. Capaldo
, Fusheng Guo
, Kevin H. Liu
, Anne C. Rios
, Nicholas Lim
, Andrew J. Kueh
, David M. Virshup
, Marco J. Herold
, Haley O. Tucker
, Gordon K. Smyth
, Geoffrey J. Lindeman
, Jane E. Visvader

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

32 Citaten (Scopus)

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Fu et al. show that the transcriptional repressor Foxp1 is crucial for governing the exit of mammary stem cells from quiescence. Moreover, Tspan8 was identified as a direct Foxp1 target that plays a functional role in regulating the stem cell state, and its deletion reversed the effects of Foxp1 loss.

Originele taal-2	Engels
Pagina's (van-tot)	629-644.e8
Tijdschrift	Developmental Cell
Volume	47
Nummer van het tijdschrift	5
DOI's	https://doi.org/10.1016/j.devcel.2018.10.001
Status	Gepubliceerd - 3 dec. 2018
Extern gepubliceerd	Ja

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10.1016/j.devcel.2018.10.001

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Fu, N. Y., Pal, B., Chen, Y., Jackling, F. C., Milevskiy, M., Vaillant, F., Capaldo, B. D., Guo, F., Liu, K. H., Rios, A. C., Lim, N., Kueh, A. J., Virshup, D. M., Herold, M. J., Tucker, H. O., Smyth, G. K., Lindeman, G. J., & Visvader, J. E. (2018). Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence. Developmental Cell, 47(5), 629-644.e8. https://doi.org/10.1016/j.devcel.2018.10.001

@article{49520948f354447fa707804151916ce1,

title = "Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence",

abstract = "Fu et al. show that the transcriptional repressor Foxp1 is crucial for governing the exit of mammary stem cells from quiescence. Moreover, Tspan8 was identified as a direct Foxp1 target that plays a functional role in regulating the stem cell state, and its deletion reversed the effects of Foxp1 loss.",

keywords = "Fox transcription factors, Foxp1, Lgr5, Tetraspanin, Tspan8, Wnt, mammary gland development, mammary stem cell, quiescence",

author = "Fu, \{Nai Yang\} and Bhupinder Pal and Yunshun Chen and Jackling, \{Felicity C.\} and Michael Milevskiy and Fran{\c c}ois Vaillant and Capaldo, \{Bianca D.\} and Fusheng Guo and Liu, \{Kevin H.\} and Rios, \{Anne C.\} and Nicholas Lim and Kueh, \{Andrew J.\} and Virshup, \{David M.\} and Herold, \{Marco J.\} and Tucker, \{Haley O.\} and Smyth, \{Gordon K.\} and Lindeman, \{Geoffrey J.\} and Visvader, \{Jane E.\}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

month = dec,

day = "3",

doi = "10.1016/j.devcel.2018.10.001",

language = "English",

volume = "47",

pages = "629--644.e8",

journal = "Developmental Cell",

issn = "1534-5807",

publisher = "Cell Press",

number = "5",

}

Fu, NY, Pal, B, Chen, Y, Jackling, FC, Milevskiy, M, Vaillant, F, Capaldo, BD, Guo, F, Liu, KH, Rios, AC, Lim, N, Kueh, AJ, Virshup, DM, Herold, MJ, Tucker, HO, Smyth, GK, Lindeman, GJ & Visvader, JE 2018, 'Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence', Developmental Cell, vol. 47, nr. 5, blz. 629-644.e8. https://doi.org/10.1016/j.devcel.2018.10.001

TY - JOUR

T1 - Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

AU - Fu, Nai Yang

AU - Pal, Bhupinder

AU - Chen, Yunshun

AU - Jackling, Felicity C.

AU - Milevskiy, Michael

AU - Vaillant, François

AU - Capaldo, Bianca D.

AU - Guo, Fusheng

AU - Liu, Kevin H.

AU - Rios, Anne C.

AU - Lim, Nicholas

AU - Kueh, Andrew J.

AU - Virshup, David M.

AU - Herold, Marco J.

AU - Tucker, Haley O.

AU - Smyth, Gordon K.

AU - Lindeman, Geoffrey J.

AU - Visvader, Jane E.

PY - 2018/12/3

Y1 - 2018/12/3

N2 - Fu et al. show that the transcriptional repressor Foxp1 is crucial for governing the exit of mammary stem cells from quiescence. Moreover, Tspan8 was identified as a direct Foxp1 target that plays a functional role in regulating the stem cell state, and its deletion reversed the effects of Foxp1 loss.

AB - Fu et al. show that the transcriptional repressor Foxp1 is crucial for governing the exit of mammary stem cells from quiescence. Moreover, Tspan8 was identified as a direct Foxp1 target that plays a functional role in regulating the stem cell state, and its deletion reversed the effects of Foxp1 loss.

KW - Fox transcription factors

KW - Foxp1

KW - Lgr5

KW - Tetraspanin

KW - Tspan8

KW - Wnt

KW - mammary gland development

KW - mammary stem cell

KW - quiescence

UR - https://www.scopus.com/pages/publications/85057291875

U2 - 10.1016/j.devcel.2018.10.001

DO - 10.1016/j.devcel.2018.10.001

M3 - Article

C2 - 30523786

AN - SCOPUS:85057291875

SN - 1534-5807

VL - 47

SP - 629-644.e8

JO - Developmental Cell

JF - Developmental Cell

IS - 5

ER -

Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

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