Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

Nai Yang Fu; Bhupinder Pal; Yunshun Chen; Felicity C. Jackling; Michael Milevskiy; François Vaillant; Bianca D. Capaldo; Fusheng Guo; Kevin H. Liu; Anne C. Rios; Nicholas Lim; Andrew J. Kueh; David M. Virshup; Marco J. Herold; Haley O. Tucker; Gordon K. Smyth; Geoffrey J. Lindeman; Jane E. Visvader

doi:10.1016/j.devcel.2018.10.001

Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

Nai Yang Fu, Bhupinder Pal, Yunshun Chen, Felicity C. Jackling, Michael Milevskiy, François Vaillant, Bianca D. Capaldo, Fusheng Guo, Kevin H. Liu, Anne C. Rios, Nicholas Lim, Andrew J. Kueh, David M. Virshup, Marco J. Herold, Haley O. Tucker, Gordon K. Smyth, Geoffrey J. Lindeman, Jane E. Visvader

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29 Citaten (Scopus)

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Fu et al. show that the transcriptional repressor Foxp1 is crucial for governing the exit of mammary stem cells from quiescence. Moreover, Tspan8 was identified as a direct Foxp1 target that plays a functional role in regulating the stem cell state, and its deletion reversed the effects of Foxp1 loss.

Originele taal-2	Engels
Pagina's (van-tot)	629-644.e8
Tijdschrift	Developmental Cell
Volume	47
Nummer van het tijdschrift	5
DOI's	https://doi.org/10.1016/j.devcel.2018.10.001
Status	Gepubliceerd - 3 dec. 2018
Extern gepubliceerd	Ja

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10.1016/j.devcel.2018.10.001

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Fu, N. Y., Pal, B., Chen, Y., Jackling, F. C., Milevskiy, M., Vaillant, F., Capaldo, B. D., Guo, F., Liu, K. H., Rios, A. C., Lim, N., Kueh, A. J., Virshup, D. M., Herold, M. J., Tucker, H. O., Smyth, G. K., Lindeman, G. J., & Visvader, J. E. (2018). Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence. Developmental Cell, 47(5), 629-644.e8. https://doi.org/10.1016/j.devcel.2018.10.001

@article{49520948f354447fa707804151916ce1,

title = "Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence",

abstract = "Fu et al. show that the transcriptional repressor Foxp1 is crucial for governing the exit of mammary stem cells from quiescence. Moreover, Tspan8 was identified as a direct Foxp1 target that plays a functional role in regulating the stem cell state, and its deletion reversed the effects of Foxp1 loss.",

keywords = "Fox transcription factors, Foxp1, Lgr5, Tetraspanin, Tspan8, Wnt, mammary gland development, mammary stem cell, quiescence",

author = "Fu, \{Nai Yang\} and Bhupinder Pal and Yunshun Chen and Jackling, \{Felicity C.\} and Michael Milevskiy and Fran{\c c}ois Vaillant and Capaldo, \{Bianca D.\} and Fusheng Guo and Liu, \{Kevin H.\} and Rios, \{Anne C.\} and Nicholas Lim and Kueh, \{Andrew J.\} and Virshup, \{David M.\} and Herold, \{Marco J.\} and Tucker, \{Haley O.\} and Smyth, \{Gordon K.\} and Lindeman, \{Geoffrey J.\} and Visvader, \{Jane E.\}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

month = dec,

day = "3",

doi = "10.1016/j.devcel.2018.10.001",

language = "English",

volume = "47",

pages = "629--644.e8",

journal = "Developmental Cell",

issn = "1534-5807",

publisher = "Cell Press",

number = "5",

}

Fu, NY, Pal, B, Chen, Y, Jackling, FC, Milevskiy, M, Vaillant, F, Capaldo, BD, Guo, F, Liu, KH, Rios, AC, Lim, N, Kueh, AJ, Virshup, DM, Herold, MJ, Tucker, HO, Smyth, GK, Lindeman, GJ & Visvader, JE 2018, 'Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence', Developmental Cell, vol. 47, nr. 5, blz. 629-644.e8. https://doi.org/10.1016/j.devcel.2018.10.001

TY - JOUR

T1 - Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

AU - Fu, Nai Yang

AU - Pal, Bhupinder

AU - Chen, Yunshun

AU - Jackling, Felicity C.

AU - Milevskiy, Michael

AU - Vaillant, François

AU - Capaldo, Bianca D.

AU - Guo, Fusheng

AU - Liu, Kevin H.

AU - Rios, Anne C.

AU - Lim, Nicholas

AU - Kueh, Andrew J.

AU - Virshup, David M.

AU - Herold, Marco J.

AU - Tucker, Haley O.

AU - Smyth, Gordon K.

AU - Lindeman, Geoffrey J.

AU - Visvader, Jane E.

PY - 2018/12/3

Y1 - 2018/12/3

N2 - Fu et al. show that the transcriptional repressor Foxp1 is crucial for governing the exit of mammary stem cells from quiescence. Moreover, Tspan8 was identified as a direct Foxp1 target that plays a functional role in regulating the stem cell state, and its deletion reversed the effects of Foxp1 loss.

AB - Fu et al. show that the transcriptional repressor Foxp1 is crucial for governing the exit of mammary stem cells from quiescence. Moreover, Tspan8 was identified as a direct Foxp1 target that plays a functional role in regulating the stem cell state, and its deletion reversed the effects of Foxp1 loss.

KW - Fox transcription factors

KW - Foxp1

KW - Lgr5

KW - Tetraspanin

KW - Tspan8

KW - Wnt

KW - mammary gland development

KW - mammary stem cell

KW - quiescence

UR - https://www.scopus.com/pages/publications/85057291875

U2 - 10.1016/j.devcel.2018.10.001

DO - 10.1016/j.devcel.2018.10.001

M3 - Article

C2 - 30523786

AN - SCOPUS:85057291875

SN - 1534-5807

VL - 47

SP - 629-644.e8

JO - Developmental Cell

JF - Developmental Cell

IS - 5

ER -

Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

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