From the bench of molecular understanding to the bedside of optimal therapy for BCR::ABL1 and ABL-class acute lymphoblastic leukemia in children and adolescents

Sarah K. Tasian; Judith M. Boer; Monique L. den Boer

doi:10.1016/j.ejcped.2025.100304

From the bench of molecular understanding to the bedside of optimal therapy for BCR::ABL1 and ABL-class acute lymphoblastic leukemia in children and adolescents

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

3 Citaten (Scopus)

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This review aims to discuss similarities and dissimilarities between BCR::ABL1-rearranged (Philadelphia chromosome-positive [Ph+]) and ABL-class fusion-driven BCR::ABL1-like (Ph-like) acute lymphoblastic leukemia (ALL) in children and adolescents. Recent insights into the biology of these historically high-risk leukemias, modern laboratory diagnostics, current treatment approaches, potential causes of treatment failure, emerging new targeted therapies and immunotherapeutic approaches for patients will be discussed. While the primary focus of this review is upon children and adolescents with BCR::ABL1-positive and ABL-class ALL, extended knowledge from recent adult clinical trials will also be addressed.

Originele taal-2	Engels
Artikelnummer	100304
Tijdschrift	EJC Paediatric Oncology
Volume	6
DOI's	https://doi.org/10.1016/j.ejcped.2025.100304
Status	Gepubliceerd - dec. 2025

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10.1016/j.ejcped.2025.100304

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title = "From the bench of molecular understanding to the bedside of optimal therapy for BCR::ABL1 and ABL-class acute lymphoblastic leukemia in children and adolescents",

abstract = "This review aims to discuss similarities and dissimilarities between BCR::ABL1-rearranged (Philadelphia chromosome-positive [Ph+]) and ABL-class fusion-driven BCR::ABL1-like (Ph-like) acute lymphoblastic leukemia (ALL) in children and adolescents. Recent insights into the biology of these historically high-risk leukemias, modern laboratory diagnostics, current treatment approaches, potential causes of treatment failure, emerging new targeted therapies and immunotherapeutic approaches for patients will be discussed. While the primary focus of this review is upon children and adolescents with BCR::ABL1-positive and ABL-class ALL, extended knowledge from recent adult clinical trials will also be addressed.",

keywords = "ABL-class, Acute lymphoblastic leukemia, BCR::ABL1, BCR::ABL1-like, Children, Clinical trials, Genetics, Immunotherapy, Ph+, Ph-like, Targeted therapy, Tyrosine kinase inhibitor",

author = "Tasian, \{Sarah K.\} and Boer, \{Judith M.\} and \{den Boer\}, \{Monique L.\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Authors",

year = "2025",

month = dec,

doi = "10.1016/j.ejcped.2025.100304",

language = "English",

volume = "6",

journal = "EJC Paediatric Oncology",

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AU - Boer, Judith M.

AU - den Boer, Monique L.

PY - 2025/12

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AB - This review aims to discuss similarities and dissimilarities between BCR::ABL1-rearranged (Philadelphia chromosome-positive [Ph+]) and ABL-class fusion-driven BCR::ABL1-like (Ph-like) acute lymphoblastic leukemia (ALL) in children and adolescents. Recent insights into the biology of these historically high-risk leukemias, modern laboratory diagnostics, current treatment approaches, potential causes of treatment failure, emerging new targeted therapies and immunotherapeutic approaches for patients will be discussed. While the primary focus of this review is upon children and adolescents with BCR::ABL1-positive and ABL-class ALL, extended knowledge from recent adult clinical trials will also be addressed.

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KW - Acute lymphoblastic leukemia

KW - BCR::ABL1

KW - BCR::ABL1-like

KW - Children

KW - Clinical trials

KW - Genetics

KW - Immunotherapy

KW - Ph+

KW - Ph-like

KW - Targeted therapy

KW - Tyrosine kinase inhibitor

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From the bench of molecular understanding to the bedside of optimal therapy for BCR::ABL1 and ABL-class acute lymphoblastic leukemia in children and adolescents

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