TY - JOUR
T1 - Function and regulation of the channel-kinase TRPM7 in health and disease
AU - Visser, Daan
AU - Middelbeek, Jeroen
AU - van Leeuwen, Frank N
AU - Jalink, Kees
N1 - Copyright © 2014 Elsevier GmbH. All rights reserved.
PY - 2014/10
Y1 - 2014/10
N2 - Transient receptor potential (TRP) cation channels represent a large and diverse family of ion channels that act as important transducers of sensory information. The Melastatin subfamily member TRPM7 has garnered much interest due to its functional kinase domain; a unique feature among ion channels. TRPM7 primarily conducts Ca(2+) and Mg(2+) and its activity is regulated by intracellular Mg(2+), phospholipase C-mediated signaling and mechanical cues. A growing number of studies emphasize a regulatory role for TRPM7 in proliferation and cell survival as well as cytoskeletal reorganization during adhesion and migration. Knockout approaches in animal models have revealed that TRPM7 significantly contributes to embryonic development and organogenesis. In addition, a role for TRPM7 to the pathophysiology of several diseases has become evident in recent years. Here, we discuss how recent insights have contributed to our understanding of TRPM7 function and regulation in health and disease.
AB - Transient receptor potential (TRP) cation channels represent a large and diverse family of ion channels that act as important transducers of sensory information. The Melastatin subfamily member TRPM7 has garnered much interest due to its functional kinase domain; a unique feature among ion channels. TRPM7 primarily conducts Ca(2+) and Mg(2+) and its activity is regulated by intracellular Mg(2+), phospholipase C-mediated signaling and mechanical cues. A growing number of studies emphasize a regulatory role for TRPM7 in proliferation and cell survival as well as cytoskeletal reorganization during adhesion and migration. Knockout approaches in animal models have revealed that TRPM7 significantly contributes to embryonic development and organogenesis. In addition, a role for TRPM7 to the pathophysiology of several diseases has become evident in recent years. Here, we discuss how recent insights have contributed to our understanding of TRPM7 function and regulation in health and disease.
KW - Animals
KW - Cardiovascular Diseases/metabolism
KW - Cell Proliferation
KW - Cell Survival
KW - Cytoskeleton/physiology
KW - Embryonic Development
KW - Humans
KW - Ion Channel Gating
KW - Ischemia/metabolism
KW - Magnesium/metabolism
KW - Neoplasms/metabolism
KW - Neurodegenerative Diseases/metabolism
KW - Protein Serine-Threonine Kinases/metabolism
KW - TRPM Cation Channels/metabolism
U2 - 10.1016/j.ejcb.2014.07.001
DO - 10.1016/j.ejcb.2014.07.001
M3 - Review article
C2 - 25073440
VL - 93
SP - 455
EP - 465
JO - European journal of cell biology
JF - European journal of cell biology
SN - 0171-9335
IS - 10-12
ER -