Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity

Keyphrases

• Functional Analysis 100%
• Liver Kinase B1 (LKB1) 100%
• Peutz-Jeghers 100%
• Cell Polarity 100%
• C-terminal Region 100%
• AMP-activated Protein Kinase Pathway 100%
• Peutz-Jeghers Syndrome 27%
• Missense mutation 18%
• AMP-activated Protein Kinase 18%
• Germline mutation 9%
• Growth Arrest 9%
• Tumor Suppressor Activity 9%
• Functional Consequences 9%
• Downstream Signaling 9%
• Cell-to-cell 9%
• Astrocytes 9%
• Kinase Activity 9%
• Mutational Analysis 9%
• Induced Growth 9%
• Regulatory Role 9%
• Enzymatic Activity 9%
• Intestinal Epithelial Cells 9%
• Sporadic Tumors 9%
• Cell Polarization 9%
• Cell Metabolism 9%
• LKB1 Gene 9%
• Non-catalytic 9%
• Protein Kinase Signaling 9%
• LKB1 Kinase 9%
• Serine/threonine Kinase 9%

Immunology and Microbiology

• Carboxy Terminal Sequence 100%
• Cell Polarity 100%
• Phosphotransferase 100%
• Kinase 100%
• Missense Mutation 40%
• Germline Mutation 20%
• Cell Cycle 20%
• Enzyme Activity 20%
• Astrocyte 20%
• Serine 20%
• Threonine 20%

Neuroscience

• C-Terminus 100%
• Cell Polarity 100%
• AMP-activated Protein Kinase 100%
• Missense Mutation 40%
• Cell Cycle 20%
• Astrocyte 20%
• Enzyme Activity 20%
• Metabolic Pathway 20%
• Germ Cell 20%
• Growth Disorder 20%
• Epithelial Cells 20%
• Protein Kinase LKB1 20%
• Tumor Suppressor Protein 20%
• Protein Serine Threonine Kinase 20%