Samenvatting
Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood cancer. We performed a chemical screen in patient-derived DIPG cultures along with RNA-seq analyses and integrated computational modeling to identify potentially effective therapeutic strategies. The multi-histone deacetylase inhibitor panobinostat demonstrated therapeutic efficacy both in vitro and in DIPG orthotopic xenograft models. Combination testing of panobinostat and the histone demethylase inhibitor GSK-J4 revealed that the two had synergistic effects. Together, these data suggest a promising therapeutic strategy for DIPG.
Originele taal-2 | Engels |
---|---|
Pagina's (van-tot) | 55-59 |
Aantal pagina's | 5 |
Tijdschrift | Nature medicine |
Volume | 21 |
Nummer van het tijdschrift | 6 |
DOI's | |
Status | Gepubliceerd - jun. 2015 |
Extern gepubliceerd | Ja |