GeneSeeker: Extraction and integration of human disease-related information from web-based genetic databases

M. A. van Driel; K. Cuelenaere; P. P.C.W. Kemmeren; J. A.M. Leunissen; H. G. Brunner; Gert Vriend

doi:10.1093/nar/gki435

GeneSeeker: Extraction and integration of human disease-related information from web-based genetic databases

M. A. van Driel, K. Cuelenaere, P. P.C.W. Kemmeren, J. A.M. Leunissen, H. G. Brunner, Gert Vriend

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

77 Citaten (Scopus)

Samenvatting

The identification of genes underlying human genetic disorders requires the combination of data related to cytogenetic localization, phenotypes and expression patterns, to generate a list of candidate genes. In the field of human genetics, it is normal to perform this combination analysis by hand. We report on GeneSeeker http://www.cmbi.ru.nl/ GeneSeeker/), a web server that gathers and combines data from a series of databases. All database searches are performed via the web interfaces provided with the original databases, guaranteeing that the most recent data are queried, and obviating data warehousing. GeneSeeker makes the same selection of candidate genes as the human geneticists would have performed, and thus reducing the time-consuming process to a few minutes. GeneSeeker is particularly well suited for syndromes in which the disease gene displays altered expression patterns in the affected tissue(s).

Originele taal-2	Engels
Pagina's (van-tot)	W758-W761
Tijdschrift	Nucleic Acids Research
Volume	33
Nummer van het tijdschrift	SUPPL. 2
DOI's	https://doi.org/10.1093/nar/gki435
Status	Gepubliceerd - jul. 2005
Extern gepubliceerd	Ja

Toegang tot document

10.1093/nar/gki435

Citeer dit

@article{01d631a35777484281c7e0282fc58e9c,

title = "GeneSeeker: Extraction and integration of human disease-related information from web-based genetic databases",

abstract = "The identification of genes underlying human genetic disorders requires the combination of data related to cytogenetic localization, phenotypes and expression patterns, to generate a list of candidate genes. In the field of human genetics, it is normal to perform this combination analysis by hand. We report on GeneSeeker http://www.cmbi.ru.nl/ GeneSeeker/), a web server that gathers and combines data from a series of databases. All database searches are performed via the web interfaces provided with the original databases, guaranteeing that the most recent data are queried, and obviating data warehousing. GeneSeeker makes the same selection of candidate genes as the human geneticists would have performed, and thus reducing the time-consuming process to a few minutes. GeneSeeker is particularly well suited for syndromes in which the disease gene displays altered expression patterns in the affected tissue(s).",

author = "{van Driel}, {M. A.} and K. Cuelenaere and Kemmeren, {P. P.C.W.} and Leunissen, {J. A.M.} and Brunner, {H. G.} and Gert Vriend",

note = "Funding Information: We thank David Thomas for helpful corrections to the manuscript. This work was supported by NWO/Unilever, the Irene Kinderziekenhuis Foundation and the EU FP6 Programme (LHSG-CT-2003-503265). Funding to pay the Open Access publication charges for this article was provided by Radboud University Nijmegen.",

year = "2005",

month = jul,

doi = "10.1093/nar/gki435",

language = "English",

volume = "33",

pages = "W758--W761",

journal = "Nucleic Acids Research",

issn = "0305-1048",

publisher = "Oxford University Press",

number = "SUPPL. 2",

}

TY - JOUR

T1 - GeneSeeker

T2 - Extraction and integration of human disease-related information from web-based genetic databases

AU - van Driel, M. A.

AU - Cuelenaere, K.

AU - Kemmeren, P. P.C.W.

AU - Leunissen, J. A.M.

AU - Brunner, H. G.

AU - Vriend, Gert

N1 - Funding Information: We thank David Thomas for helpful corrections to the manuscript. This work was supported by NWO/Unilever, the Irene Kinderziekenhuis Foundation and the EU FP6 Programme (LHSG-CT-2003-503265). Funding to pay the Open Access publication charges for this article was provided by Radboud University Nijmegen.

PY - 2005/7

Y1 - 2005/7

N2 - The identification of genes underlying human genetic disorders requires the combination of data related to cytogenetic localization, phenotypes and expression patterns, to generate a list of candidate genes. In the field of human genetics, it is normal to perform this combination analysis by hand. We report on GeneSeeker http://www.cmbi.ru.nl/ GeneSeeker/), a web server that gathers and combines data from a series of databases. All database searches are performed via the web interfaces provided with the original databases, guaranteeing that the most recent data are queried, and obviating data warehousing. GeneSeeker makes the same selection of candidate genes as the human geneticists would have performed, and thus reducing the time-consuming process to a few minutes. GeneSeeker is particularly well suited for syndromes in which the disease gene displays altered expression patterns in the affected tissue(s).

AB - The identification of genes underlying human genetic disorders requires the combination of data related to cytogenetic localization, phenotypes and expression patterns, to generate a list of candidate genes. In the field of human genetics, it is normal to perform this combination analysis by hand. We report on GeneSeeker http://www.cmbi.ru.nl/ GeneSeeker/), a web server that gathers and combines data from a series of databases. All database searches are performed via the web interfaces provided with the original databases, guaranteeing that the most recent data are queried, and obviating data warehousing. GeneSeeker makes the same selection of candidate genes as the human geneticists would have performed, and thus reducing the time-consuming process to a few minutes. GeneSeeker is particularly well suited for syndromes in which the disease gene displays altered expression patterns in the affected tissue(s).

UR - http://www.scopus.com/inward/record.url?scp=23144443079&partnerID=8YFLogxK

U2 - 10.1093/nar/gki435

DO - 10.1093/nar/gki435

M3 - Article

C2 - 15980578

AN - SCOPUS:23144443079

SN - 0305-1048

VL - 33

SP - W758-W761

JO - Nucleic Acids Research

JF - Nucleic Acids Research

IS - SUPPL. 2

ER -

GeneSeeker: Extraction and integration of human disease-related information from web-based genetic databases

Samenvatting

Toegang tot document

Vingerafdruk

Citeer dit