TY - JOUR
T1 - Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes
AU - Siezen, Christine L.E.
AU - Bont, Louis
AU - Hodemaekers, Hennie M.
AU - Ermers, Marieke J.
AU - Doornbos, Gerda
AU - Vant Slot, Ruben
AU - Wijmenga, Ciska
AU - Houwelingen, Hans C.Van
AU - Kimpen, Jan L.L.
AU - Kimman, Tjeerd G.
AU - Hoebee, Barbara
AU - Janssen, Riny
PY - 2009/4
Y1 - 2009/4
N2 - Prematurity is a risk factor for severe respiratory syncytial virus bronchiolitis. We show that genetic factors in innate immune genes (IFNA13, IFNAR2, STAT2, IL27, NFKBIA, C3, IL1RN, TLR5), in innate and adaptive immunity (IFNG), and in airway remodeling genes (ADAM33 and TGFBR1), affect disease susceptibility to a different extent in preterm children, born with underdeveloped lungs, than in term children.
AB - Prematurity is a risk factor for severe respiratory syncytial virus bronchiolitis. We show that genetic factors in innate immune genes (IFNA13, IFNAR2, STAT2, IL27, NFKBIA, C3, IL1RN, TLR5), in innate and adaptive immunity (IFNG), and in airway remodeling genes (ADAM33 and TGFBR1), affect disease susceptibility to a different extent in preterm children, born with underdeveloped lungs, than in term children.
KW - Bronchiolitis
KW - Host-genetics
KW - Preterm
KW - RSV
UR - http://www.scopus.com/inward/record.url?scp=65649136910&partnerID=8YFLogxK
U2 - 10.1097/INF.0b013e31818e2aa9
DO - 10.1097/INF.0b013e31818e2aa9
M3 - Article
C2 - 19258923
AN - SCOPUS:65649136910
SN - 0891-3668
VL - 28
SP - 333
EP - 335
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
IS - 4
ER -