Genome-wide functions of PML-RARα in acute promyelocytic leukaemia

S. Saeed; C. Logie; H. G. Stunnenberg; J. H.A. Martens

doi:10.1038/sj.bjc.6606095

Genome-wide functions of PML-RARα in acute promyelocytic leukaemia

S. Saeed, C. Logie, H. G. Stunnenberg, J. H.A. Martens

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

59 Citaten (Scopus)

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PMLRAR (retinoic acid receptor)α is the hallmark protein of acute promyelocytic leukaemia, a highly malignant subtype of acute myeloid leukaemia that accounts for approximately 10% of all AML cases. Recently, several studies have been set out to obtain a comprehensive genome-wide view of the molecular actions of this chimeric protein. In this review, we highlight the new insights that arose from these studies, in particular focussing on newly identified PML-RARα target genes, its interplay with RXR and deregulation of epigenetic modifications.

Originele taal-2	Engels
Pagina's (van-tot)	554-558
Aantal pagina's	5
Tijdschrift	British journal of cancer
Volume	104
Nummer van het tijdschrift	4
DOI's	https://doi.org/10.1038/sj.bjc.6606095
Status	Gepubliceerd - 15 feb. 2011
Extern gepubliceerd	Ja

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title = "Genome-wide functions of PML-RARα in acute promyelocytic leukaemia",

abstract = "PMLRAR (retinoic acid receptor)α is the hallmark protein of acute promyelocytic leukaemia, a highly malignant subtype of acute myeloid leukaemia that accounts for approximately 10\% of all AML cases. Recently, several studies have been set out to obtain a comprehensive genome-wide view of the molecular actions of this chimeric protein. In this review, we highlight the new insights that arose from these studies, in particular focussing on newly identified PML-RARα target genes, its interplay with RXR and deregulation of epigenetic modifications.",

keywords = "PML-RARa, PU.1 (SPI1), RXR, epigenome",

author = "S. Saeed and C. Logie and Stunnenberg, \{H. G.\} and Martens, \{J. H.A.\}",

note = "Funding Information: This work was supported by the European Union LSHC-CT-2005-518417 {\textquoteleft}Epitron{\textquoteright} and the Dutch Cancer Foundation (KWF KUN 2009-4527) and Higher Education Commission of Pakistan.",

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AU - Logie, C.

AU - Stunnenberg, H. G.

AU - Martens, J. H.A.

N1 - Funding Information: This work was supported by the European Union LSHC-CT-2005-518417 ‘Epitron’ and the Dutch Cancer Foundation (KWF KUN 2009-4527) and Higher Education Commission of Pakistan.

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N2 - PMLRAR (retinoic acid receptor)α is the hallmark protein of acute promyelocytic leukaemia, a highly malignant subtype of acute myeloid leukaemia that accounts for approximately 10% of all AML cases. Recently, several studies have been set out to obtain a comprehensive genome-wide view of the molecular actions of this chimeric protein. In this review, we highlight the new insights that arose from these studies, in particular focussing on newly identified PML-RARα target genes, its interplay with RXR and deregulation of epigenetic modifications.

AB - PMLRAR (retinoic acid receptor)α is the hallmark protein of acute promyelocytic leukaemia, a highly malignant subtype of acute myeloid leukaemia that accounts for approximately 10% of all AML cases. Recently, several studies have been set out to obtain a comprehensive genome-wide view of the molecular actions of this chimeric protein. In this review, we highlight the new insights that arose from these studies, in particular focussing on newly identified PML-RARα target genes, its interplay with RXR and deregulation of epigenetic modifications.

KW - PML-RARa

KW - PU.1 (SPI1)

KW - RXR

KW - epigenome

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M3 - Review article

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ER -

Genome-wide functions of PML-RARα in acute promyelocytic leukaemia

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