Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits

Keyphrases

• Meta-analysis 100%
• Growth Factors 100%
• Aging Characteristics 100%
• Insulin-like 100%
• Three-level 100%
• IGF-binding protein-3 100%
• SNP 25%
• Forkhead Box O3 (FOXO3) 25%
• Insulin-like Growth Factor Binding protein-3 (IGFBP-3) 25%
• ASXL2 25%
• IGFALS 16%
• SorCS2 16%
• CELSR2 16%
• Protein Level 8%
• Genome-wide Association Study 8%
• Gene Expression Level 8%
• Cardiovascular Disease 8%
• Expression Quantitative Trait Loci (eQTL) 8%
• Human Disease 8%
• Regulatory Elements 8%
• Growth Factor Binding 8%
• Binding Protein 8%
• Growth Hormone 8%
• Bioinformatics Analysis 8%
• European Ancestry 8%
• Genotype-phenotype 8%
• Significant SNPs 8%
• Adiposity 8%
• Diabetes 8%
• Insulin-like Growth factor-1 8%
• Mediating Effect 8%
• Growth Hormone Secretagogue Receptor (GHS-R) 8%
• Sex Interaction 8%
• TNS3 8%

Biochemistry, Genetics and Molecular Biology

• Binding Protein 100%
• Insulin-Like Growth Factor 1 100%
• Single Nucleotide Polymorphism 44%
• Insulin-Like Growth Factor 33%
• FOXO3 33%
• IGFBP3 33%
• Animal Model 11%
• Allele 11%
• Gene Expression 11%
• Regulatory Element 11%
• Insulin-Like Growth Factor-Binding Protein 11%
• Bovine Somatotropin 11%
• Growth Hormone 11%