Genomic actions of estrogen receptor α: What are the targets and how are they regulated?

Willem Jan Welboren, Fred C.G.J. Sweep, Paul N. Span, Hendrik G. Stunnenberg

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

130 Citaten (Scopus)

Samenvatting

The estrogen receptor α (ERα) is a ligand-dependent transcription factor that regulates a large number of genes in many different target tissues and is important in the development and progression of breast cancer. ERα-mediated transcription is a complex process regulated at many different levels. The interplay between ligand, receptor, DNA sequence, cofactors, chromatin context, and post-translational modifications culminates in transcriptional regulation by ERα. Recent technological advances have allowed the identification of ERα target genes on a genomewide scale. In this review, we provide an overview of the progress made in our understanding of the different levels of regulation mediated by ERα. We discuss the recent advances in the identification of the ERα-binding sites and target gene network and their clinical applications.

Originele taal-2Engels
Pagina's (van-tot)1073-1089
Aantal pagina's17
TijdschriftEndocrine-Related Cancer
Volume16
Nummer van het tijdschrift4
DOI's
StatusGepubliceerd - dec. 2009
Extern gepubliceerdJa

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