TY - JOUR
T1 - Genomic alterations in well-differentiated gastrointestinal and bronchial neuroendocrine tumors (carcinoids)
T2 - Marked differences indicating diversity in molecular pathogenesis
AU - Zhao, Jianming
AU - De Krijger, Roland R.
AU - Meier, Dorette
AU - Speel, Ernst Jan M.
AU - Saremaslani, Parvin
AU - Muletta-Feurer, Seraina
AU - Matter, Claudia
AU - Roth, Jürgen
AU - Heitz, Philipp U.
AU - Komminoth, Paul
N1 - Funding Information:
Supported by the Swiss National Science Foundation and the Swiss Cancer League.
PY - 2000
Y1 - 2000
N2 - Neuroendocrine tumors (carcinoids) are a heterogeneous group of neoplasms arising from the diffuse neuroendocrine system. Genetic changes underlying their tumorigenesis are primarily unknown. We used comparative genomic hybridization to screen 32 welldifferentiated neuroendocrine tumors (21 gastrointestinal and 11 bronchial) and three associated metastases for genomic alterations. There were striking differences of genomic imbalances between the two subgroups of neuroendocrine tumors. Losses of chromosome 18q and 18p were shown in eight (38%) and seven (33%), respectively, out of 21 gastrointestinal tumors and in none of the 11 bronchial tumors. Conversely, deletions of 11q occurred in four of 11 (36%) bronchial tumors but only in one gastrointestinal tumor. These comparative genomic hybridization findings were confirmed by interphase cytogenetics. Our data indicate that neuroendocrine tumors of the two subgroups develop via different molecular pathways. Inactivation of one or several tumor suppressor genes on chromosome 18 may be important for the biological behavior of gastrointestinal tumors, whereas gene inactivation on 11q seems to be associated with tumor development of the bronchi.
AB - Neuroendocrine tumors (carcinoids) are a heterogeneous group of neoplasms arising from the diffuse neuroendocrine system. Genetic changes underlying their tumorigenesis are primarily unknown. We used comparative genomic hybridization to screen 32 welldifferentiated neuroendocrine tumors (21 gastrointestinal and 11 bronchial) and three associated metastases for genomic alterations. There were striking differences of genomic imbalances between the two subgroups of neuroendocrine tumors. Losses of chromosome 18q and 18p were shown in eight (38%) and seven (33%), respectively, out of 21 gastrointestinal tumors and in none of the 11 bronchial tumors. Conversely, deletions of 11q occurred in four of 11 (36%) bronchial tumors but only in one gastrointestinal tumor. These comparative genomic hybridization findings were confirmed by interphase cytogenetics. Our data indicate that neuroendocrine tumors of the two subgroups develop via different molecular pathways. Inactivation of one or several tumor suppressor genes on chromosome 18 may be important for the biological behavior of gastrointestinal tumors, whereas gene inactivation on 11q seems to be associated with tumor development of the bronchi.
UR - http://www.scopus.com/inward/record.url?scp=0033693557&partnerID=8YFLogxK
U2 - 10.1016/S0002-9440(10)64780-3
DO - 10.1016/S0002-9440(10)64780-3
M3 - Article
C2 - 11073802
AN - SCOPUS:0033693557
SN - 0002-9440
VL - 157
SP - 1431
EP - 1438
JO - American Journal of Pathology
JF - American Journal of Pathology
IS - 5
ER -