Germ cell neoplasia in situ (GCNIS): evolution of the current nomenclature for testicular pre-invasive germ cell malignancy

Daniel M Berney; Leendert H J Looijenga; Muhammad Idrees; J Wolter Oosterhuis; Ewa Rajpert-De Meyts; Thomas M Ulbright; Niels E Skakkebaek

doi:10.1111/his.12958

Germ cell neoplasia in situ (GCNIS): evolution of the current nomenclature for testicular pre-invasive germ cell malignancy

Daniel M Berney, Leendert H J Looijenga, Muhammad Idrees, J Wolter Oosterhuis, Ewa Rajpert-De Meyts, Thomas M Ulbright, Niels E Skakkebaek

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

118 Citaten (Scopus)

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The pre-invasive lesion associated with post-pubertal malignant germ cell tumours of the testis was first recognized in the early 1970s and confirmed by a number of observational and follow-up studies. Until this year, this scientific story has been confused by resistance to the entity and disagreement on its name. Initially termed 'carcinoma in situ' (CIS), it has also been known as 'intratubular germ cell neoplasia, unclassified' (IGCNU) and 'testicular intraepithelial neoplasia' (TIN). In this paper, we review the history of discovery and controversy concerning these names and introduce the reasoning for uniting behind a new name, endorsed unanimously at the World Health Organization (WHO) consensus classification 2016: germ cell neoplasia in situ (GCNIS).

Originele taal-2	Engels
Pagina's (van-tot)	7-10
Aantal pagina's	4
Tijdschrift	Histopathology
Volume	69
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1111/his.12958
Status	Gepubliceerd - jul. 2016
Extern gepubliceerd	Ja

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@article{145ed4476ccb4402b120911b627ced59,

title = "Germ cell neoplasia in situ (GCNIS): evolution of the current nomenclature for testicular pre-invasive germ cell malignancy",

abstract = "The pre-invasive lesion associated with post-pubertal malignant germ cell tumours of the testis was first recognized in the early 1970s and confirmed by a number of observational and follow-up studies. Until this year, this scientific story has been confused by resistance to the entity and disagreement on its name. Initially termed 'carcinoma in situ' (CIS), it has also been known as 'intratubular germ cell neoplasia, unclassified' (IGCNU) and 'testicular intraepithelial neoplasia' (TIN). In this paper, we review the history of discovery and controversy concerning these names and introduce the reasoning for uniting behind a new name, endorsed unanimously at the World Health Organization (WHO) consensus classification 2016: germ cell neoplasia in situ (GCNIS). ",

keywords = "Humans, Male, Neoplasms, Germ Cell and Embryonal/classification, Spermatogonia/pathology, Terminology as Topic, Testicular Neoplasms/classification, Testis/pathology",

author = "Berney, {Daniel M} and Looijenga, {Leendert H J} and Muhammad Idrees and Oosterhuis, {J Wolter} and {Rajpert-De Meyts}, Ewa and Ulbright, {Thomas M} and Skakkebaek, {Niels E}",

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T2 - evolution of the current nomenclature for testicular pre-invasive germ cell malignancy

AU - Berney, Daniel M

AU - Looijenga, Leendert H J

AU - Idrees, Muhammad

AU - Oosterhuis, J Wolter

AU - Rajpert-De Meyts, Ewa

AU - Ulbright, Thomas M

AU - Skakkebaek, Niels E

PY - 2016/7

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N2 - The pre-invasive lesion associated with post-pubertal malignant germ cell tumours of the testis was first recognized in the early 1970s and confirmed by a number of observational and follow-up studies. Until this year, this scientific story has been confused by resistance to the entity and disagreement on its name. Initially termed 'carcinoma in situ' (CIS), it has also been known as 'intratubular germ cell neoplasia, unclassified' (IGCNU) and 'testicular intraepithelial neoplasia' (TIN). In this paper, we review the history of discovery and controversy concerning these names and introduce the reasoning for uniting behind a new name, endorsed unanimously at the World Health Organization (WHO) consensus classification 2016: germ cell neoplasia in situ (GCNIS).

AB - The pre-invasive lesion associated with post-pubertal malignant germ cell tumours of the testis was first recognized in the early 1970s and confirmed by a number of observational and follow-up studies. Until this year, this scientific story has been confused by resistance to the entity and disagreement on its name. Initially termed 'carcinoma in situ' (CIS), it has also been known as 'intratubular germ cell neoplasia, unclassified' (IGCNU) and 'testicular intraepithelial neoplasia' (TIN). In this paper, we review the history of discovery and controversy concerning these names and introduce the reasoning for uniting behind a new name, endorsed unanimously at the World Health Organization (WHO) consensus classification 2016: germ cell neoplasia in situ (GCNIS).

KW - Humans

KW - Male

KW - Neoplasms, Germ Cell and Embryonal/classification

KW - Spermatogonia/pathology

KW - Terminology as Topic

KW - Testicular Neoplasms/classification

KW - Testis/pathology

U2 - 10.1111/his.12958

DO - 10.1111/his.12958

M3 - Review article

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JO - Histopathology

JF - Histopathology

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Germ cell neoplasia in situ (GCNIS): evolution of the current nomenclature for testicular pre-invasive germ cell malignancy

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