Gonadal dysgenesis in disorders of sex development: Diagnosis and surgical management

K P Wolffenbuttel; R Hersmus; H Stoop; K Biermann; P Hoebeke; M Cools; L H J Looijenga

doi:10.1016/j.jpurol.2016.08.015

Gonadal dysgenesis in disorders of sex development: Diagnosis and surgical management

K P Wolffenbuttel, R Hersmus, H Stoop, K Biermann, P Hoebeke, M Cools, L H J Looijenga

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

53 Citaten (Scopus)

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Recent studies on gonadal histology have improved the understanding of germ cell malignancy risk in patients with disorders of sex development (DSD), and evidence-based gonadal management strategies are gradually emerging. Especially in 46,XY DSD and 45,X/46,XY DSD, which are characterized by gonadal dysgenesis, the risk of germ cell malignancy is significantly increased. This paper summarized the progress over the past 10 years in malignancy risk assessment in patients with DSD, and its implications for optimal surgical handling of the involved gonads.

Originele taal-2	Engels
Pagina's (van-tot)	411-416
Aantal pagina's	6
Tijdschrift	Journal of pediatric urology
Volume	12
Nummer van het tijdschrift	6
DOI's	https://doi.org/10.1016/j.jpurol.2016.08.015
Status	Gepubliceerd - dec. 2016
Extern gepubliceerd	Ja

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title = "Gonadal dysgenesis in disorders of sex development: Diagnosis and surgical management",

abstract = "Recent studies on gonadal histology have improved the understanding of germ cell malignancy risk in patients with disorders of sex development (DSD), and evidence-based gonadal management strategies are gradually emerging. Especially in 46,XY DSD and 45,X/46,XY DSD, which are characterized by gonadal dysgenesis, the risk of germ cell malignancy is significantly increased. This paper summarized the progress over the past 10 years in malignancy risk assessment in patients with DSD, and its implications for optimal surgical handling of the involved gonads.",

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author = "Wolffenbuttel, {K P} and R Hersmus and H Stoop and K Biermann and P Hoebeke and M Cools and Looijenga, {L H J}",

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AU - Hersmus, R

AU - Stoop, H

AU - Biermann, K

AU - Hoebeke, P

AU - Cools, M

AU - Looijenga, L H J

PY - 2016/12

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N2 - Recent studies on gonadal histology have improved the understanding of germ cell malignancy risk in patients with disorders of sex development (DSD), and evidence-based gonadal management strategies are gradually emerging. Especially in 46,XY DSD and 45,X/46,XY DSD, which are characterized by gonadal dysgenesis, the risk of germ cell malignancy is significantly increased. This paper summarized the progress over the past 10 years in malignancy risk assessment in patients with DSD, and its implications for optimal surgical handling of the involved gonads.

AB - Recent studies on gonadal histology have improved the understanding of germ cell malignancy risk in patients with disorders of sex development (DSD), and evidence-based gonadal management strategies are gradually emerging. Especially in 46,XY DSD and 45,X/46,XY DSD, which are characterized by gonadal dysgenesis, the risk of germ cell malignancy is significantly increased. This paper summarized the progress over the past 10 years in malignancy risk assessment in patients with DSD, and its implications for optimal surgical handling of the involved gonads.

KW - Child

KW - Decision Trees

KW - Female

KW - Gonadal Dysgenesis/diagnosis

KW - Humans

KW - Male

KW - Urologic Surgical Procedures/methods

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SN - 1477-5131

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SP - 411

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JO - Journal of pediatric urology

JF - Journal of pediatric urology

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ER -

Gonadal dysgenesis in disorders of sex development: Diagnosis and surgical management

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