Harnessing soft tissue sarcoma with low-dose pazopanib - A matter of blood levels

Stefanie L. Groenland, Daniela Katz, Alwin D.R. Huitema, Neeltje Steeghs

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

4 Citaten (Scopus)

Samenvatting

Background: Pazopanib is a tyrosine kinase inhibitor indicated for the treatment of renal cell carcinoma and soft tissue sarcoma. Despite the high inter-patient variability in pharmacokinetic exposure, pazopanib is administered at a fixed dose of 800 mg once daily (QD). Pharmacokinetic exposure is linked to both efficacy and toxicity. In this case report, we illustrate the value of therapeutic drug monitoring by describing two patients with adequate pazopanib trough concentrations (C min ) at an eight times lower than standard dose. Case presentation: Patient A is a 69-year-old woman with metastatic leiomyosarcoma who had significant toxicities and a high C min on the standard dose. While dose reductions to 200 mg QD and later 200 mg every other day were made, pazopanib C min remained above the efficacy threshold. Patient B is a 50-year-old male with metastatic angiosarcoma and a history of Gilbert syndrome. Pazopanib treatment was initiated at the standard dose of 800 mg QD, but was reduced to 200 mg QD 1-week-on - 1-week-off due to total bilirubin elevation. Pazopanib C min was adequate in this patient as well. Conclusion: It could be valuable to measure pazopanib levels in case of dose reductions due to toxicity, as exposure could still be adequate at considerably lower than standard doses.

Originele taal-2Engels
Artikelnummer1200
TijdschriftBMC Cancer
Volume18
Nummer van het tijdschrift1
DOI's
StatusGepubliceerd - 3 dec. 2018
Extern gepubliceerdJa

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