Health-related quality of life of children on treatment for acute lymphoblastic leukemia: A systematic review

Joanna E. Fardell; Janine Vetsch; T. Trahair; M. K. Mateos; M. A. Grootenhuis; L. M. Touyz; G. M. Marshall; C. E. Wakefield

doi:10.1002/pbc.26489

Health-related quality of life of children on treatment for acute lymphoblastic leukemia: A systematic review

Joanna E. Fardell, Janine Vetsch, T. Trahair, M. K. Mateos, M. A. Grootenhuis, L. M. Touyz, G. M. Marshall, C. E. Wakefield

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73 Citaten (Scopus)

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Children with acute lymphoblastic leukemia (ALL) undergo intense anticancer treatment. We systematically reviewed 22 studies evaluating 2,073 ALL patients’ health-related quality of life (HRQL) and its clinical/demographic correlates during treatment. Overall HRQL was significantly reduced on treatment. Despite HRQL improvements over time, longitudinal studies reported a proportion of children continued to experience reduced HRQL after treatment completion. We found inconsistent associations between clinical/demographic factors and HRQL outcomes. Tentative evidence emerged for worse HRQL being associated with intensive phases of chemotherapy, corticosteroid therapy, experiencing greater toxicity, older age, and female sex. Longitudinal studies are needed to identify children at-risk of reduced HRQL.

Originele taal-2	Engels
Artikelnummer	e26489
Tijdschrift	Pediatric Blood and Cancer
Volume	64
Nummer van het tijdschrift	9
DOI's	https://doi.org/10.1002/pbc.26489
Status	Gepubliceerd - sep. 2017
Extern gepubliceerd	Ja

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title = "Health-related quality of life of children on treatment for acute lymphoblastic leukemia: A systematic review",

abstract = "Children with acute lymphoblastic leukemia (ALL) undergo intense anticancer treatment. We systematically reviewed 22 studies evaluating 2,073 ALL patients{\textquoteright} health-related quality of life (HRQL) and its clinical/demographic correlates during treatment. Overall HRQL was significantly reduced on treatment. Despite HRQL improvements over time, longitudinal studies reported a proportion of children continued to experience reduced HRQL after treatment completion. We found inconsistent associations between clinical/demographic factors and HRQL outcomes. Tentative evidence emerged for worse HRQL being associated with intensive phases of chemotherapy, corticosteroid therapy, experiencing greater toxicity, older age, and female sex. Longitudinal studies are needed to identify children at-risk of reduced HRQL.",

keywords = "acute lymphoblastic leukemia, pediatric oncology, quality of life, systematic review, treatment",

author = "Fardell, {Joanna E.} and Janine Vetsch and T. Trahair and Mateos, {M. K.} and Grootenhuis, {M. A.} and Touyz, {L. M.} and Marshall, {G. M.} and Wakefield, {C. E.}",

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year = "2017",

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doi = "10.1002/pbc.26489",

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T1 - Health-related quality of life of children on treatment for acute lymphoblastic leukemia

T2 - A systematic review

AU - Fardell, Joanna E.

AU - Vetsch, Janine

AU - Trahair, T.

AU - Mateos, M. K.

AU - Grootenhuis, M. A.

AU - Touyz, L. M.

AU - Marshall, G. M.

AU - Wakefield, C. E.

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AB - Children with acute lymphoblastic leukemia (ALL) undergo intense anticancer treatment. We systematically reviewed 22 studies evaluating 2,073 ALL patients’ health-related quality of life (HRQL) and its clinical/demographic correlates during treatment. Overall HRQL was significantly reduced on treatment. Despite HRQL improvements over time, longitudinal studies reported a proportion of children continued to experience reduced HRQL after treatment completion. We found inconsistent associations between clinical/demographic factors and HRQL outcomes. Tentative evidence emerged for worse HRQL being associated with intensive phases of chemotherapy, corticosteroid therapy, experiencing greater toxicity, older age, and female sex. Longitudinal studies are needed to identify children at-risk of reduced HRQL.

KW - acute lymphoblastic leukemia

KW - pediatric oncology

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KW - treatment

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DO - 10.1002/pbc.26489

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JO - Pediatric Blood and Cancer

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Health-related quality of life of children on treatment for acute lymphoblastic leukemia: A systematic review

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