Height-independent estimation of glomerular filtration rate in children: An alternative to the schwartz equation

Hester N. Blufpand, Rik Westland, Joanna A.E. Van Wijk, Elianne A. Roelandse-Koop, Gertjan J.L. Kaspers, Arend Bökenkamp

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

33 Citaten (Scopus)

Samenvatting

Objective To compare the diagnostic performance of 2 height-independent equations used to calculate estimated glomerular filtration rate (eGFR), those of Pottel (eGFR-Pottel) and the British Columbia Children's Hospital (BCCH) (eGFR-BCCH), with the commonly used Schwartz equation (eGFR-Schwartz). Study design We externally validated eGFR-Pottel and eGFR-BCCH in a well-characterized pediatric patient population (n = 152) and compared their diagnostic performance with that of eGFR-Schwartz using Bland-Altman analysis. All patients underwent glomerular filtration rate measurement using the gold standard single-injection inulin clearance method (GFR-inulin). Results Median GFR-inulin was 92.0 mL/min/1.73 m (IQR, 76.1-107.4 mL/min/1.73 m 2). Compared with GFR-inulin, the mean bias for eGFR-Schwartz was -10.1 mL/min/1.73 m2 (95% limits of agreement [LOA], -77.5 to 57.2 mL/min/1.73 m2), compared with -12.3 mL/min/1.73 mÂ2 (95% LOA, -72.6 to 47.9 mL/min/1.73 m2) for eGFR-Pottel and -22.1 mL/min/1.73 mÂ2 (95% LOA, -105.0 to 60.8 mL/min/1.73 m 2) for eGFR-BCCH. eGFR-Pottel showed comparable accuracy to eGFR-Schwartz, with 77% and 76% of estimates within 30% of GFR-inulin, respectively. eGFR-BCCH was less accurate than eGFR-Schwartz (66% of estimates within 30% of GFR-inulin; P <.01). Conclusion The performance of eGFR-Pottel is superior to that of eGFR-BCCH and comparable with that of eGFR-Schwartz. eGFR-Pottel is a valid alternative to eGFR-Schwartz in children and could be reported by the laboratory if height data are not available.

Originele taal-2Engels
Pagina's (van-tot)1722-1727
Aantal pagina's6
TijdschriftJournal of Pediatrics
Volume163
Nummer van het tijdschrift6
DOI's
StatusGepubliceerd - dec. 2013
Extern gepubliceerdJa

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