High PDGFRA expression does not serve as an effective therapeutic target in ERG-deleted B-cell precursor acute lymphoblastic leukemia

Isabel S Jerchel; Danai Chatzivasileiou; Alex Q Hoogkamer; Judith M Boer; H Berna Beverloo; Rob Pieters; Monique L den Boer

doi:10.3324/haematol.2017.171702

High PDGFRA expression does not serve as an effective therapeutic target in ERG-deleted B-cell precursor acute lymphoblastic leukemia

Isabel S Jerchel, Danai Chatzivasileiou, Alex Q Hoogkamer, Judith M Boer, H Berna Beverloo, Rob Pieters, Monique L den Boer

Group Pieters

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

1 Citaat (Scopus)

Originele taal-2	Engels
Pagina's (van-tot)	e73-e77
Tijdschrift	Haematologica
Volume	103
Nummer van het tijdschrift	2
DOI's	https://doi.org/10.3324/haematol.2017.171702
Status	Gepubliceerd - feb. 2018

Toegang tot document

10.3324/haematol.2017.171702

Citeer dit

@article{31a47c80bab9414cb968b9725ec76df5,

title = "High PDGFRA expression does not serve as an effective therapeutic target in ERG-deleted B-cell precursor acute lymphoblastic leukemia",

keywords = "Cell Survival, Child, Humans, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy, Receptor, Platelet-Derived Growth Factor alpha/metabolism, Transcriptional Regulator ERG/deficiency, Treatment Failure",

author = "Jerchel, {Isabel S} and Danai Chatzivasileiou and Hoogkamer, {Alex Q} and Boer, {Judith M} and Beverloo, {H Berna} and Rob Pieters and {den Boer}, {Monique L}",

note = "Funding Information: 1Department of Pediatric Oncology, Erasmus Medical Center-Sophia Children{\textquoteright}s Hospital, Rotterdam;2Department of Clinical Genetics, Erasmus Medical Center, Rotterdam and 3Princess M{\'a}xima Center for Pediatric Oncology, Utrecht, the Netherlands Funding: this work was supported by NWO (grant 016.126.612), the Dutch Cancer Society (AMC 2008-4265 and EMCR 2014-6998), the KIKA Foundation (132 and 161) and the Pediatric Oncology Foundation Rotterdam. We thank Cergentis BV (Utrecht) for targeted locus amplification, and Judit Balog from Leiden University Medical Center for all efforts in detecting DUX4. Correspondence: [email protected] doi:10.3324/haematol.2017.171702 Information on authorship, contributions, and financial & other disclosures was provided by the authors and is available with the online version of this article at www.haematologica.org.",

year = "2018",

month = feb,

doi = "10.3324/haematol.2017.171702",

language = "English",

volume = "103",

pages = "e73--e77",

journal = "Haematologica",

issn = "0390-6078",

publisher = "Ferrata Storti Foundation",

number = "2",

}

TY - JOUR

T1 - High PDGFRA expression does not serve as an effective therapeutic target in ERG-deleted B-cell precursor acute lymphoblastic leukemia

AU - Jerchel, Isabel S

AU - Chatzivasileiou, Danai

AU - Hoogkamer, Alex Q

AU - Boer, Judith M

AU - Beverloo, H Berna

AU - Pieters, Rob

AU - den Boer, Monique L

N1 - Funding Information: 1Department of Pediatric Oncology, Erasmus Medical Center-Sophia Children’s Hospital, Rotterdam;2Department of Clinical Genetics, Erasmus Medical Center, Rotterdam and 3Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands Funding: this work was supported by NWO (grant 016.126.612), the Dutch Cancer Society (AMC 2008-4265 and EMCR 2014-6998), the KIKA Foundation (132 and 161) and the Pediatric Oncology Foundation Rotterdam. We thank Cergentis BV (Utrecht) for targeted locus amplification, and Judit Balog from Leiden University Medical Center for all efforts in detecting DUX4. Correspondence: [email protected] doi:10.3324/haematol.2017.171702 Information on authorship, contributions, and financial & other disclosures was provided by the authors and is available with the online version of this article at www.haematologica.org.

PY - 2018/2

Y1 - 2018/2

KW - Cell Survival

KW - Child

KW - Humans

KW - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy

KW - Receptor, Platelet-Derived Growth Factor alpha/metabolism

KW - Transcriptional Regulator ERG/deficiency

KW - Treatment Failure

UR - http://www.scopus.com/inward/record.url?scp=85041524826&partnerID=8YFLogxK

U2 - 10.3324/haematol.2017.171702

DO - 10.3324/haematol.2017.171702

M3 - Article

C2 - 29170250

SN - 0390-6078

VL - 103

SP - e73-e77

JO - Haematologica

JF - Haematologica

IS - 2

ER -