TY - JOUR
T1 - Histologic chorioamnionitis, fetal involvement, and antenatal steroids
T2 - effects on neonatal outcome in preterm infants
AU - Been, Jasper V.
AU - Rours, Ingrid G.I.J.G.
AU - Kornelisse, René F.
AU - Lima Passos, Valéria
AU - Kramer, Boris W.
AU - Schneider, Tom A.J.
AU - de Krijger, Ronald R.
AU - Zimmermann, Luc J.I.
N1 - Funding Information:
This study was supported in part by the Revolving Fund, Erasmus University Medical Center, Rotterdam, The Netherlands. J.V.B. is supported by a Profileringsfonds Grant from the Maastricht University Medical Center.
PY - 2009/12
Y1 - 2009/12
N2 - Objective: The objective of the study was to study the effects of histologic chorioamnionitis (HC) with or without fetal involvement and antenatal steroid (AS) exposure on neonatal outcome in a prospective cohort of preterm infants. Study Design: The clinical characteristics and placental histology were prospectively collected in 301 infants born at a gestational age 32.0 weeks or less in the Erasmus University Medical Center. Results: In univariable analyses, HC without fetal involvement (n = 53) was associated with decreased severe respiratory distress syndrome (RDS) (11% vs 28%; P < .05), whereas HC with fetal involvement infants (n = 68) had more necrotizing enterocolitis (9% vs 2%; P < .05), intraventricular hemorrhage (IVH) (25% vs 12%; P < .05), and neonatal mortality (19% vs 9%; P < .05). In HC without fetal involvement infants, AS reduced the incidences of RDS (43% vs 85%; P < .05) and IVH (5% vs 39%; P < .01). In multivariable analyses, HC without fetal involvement was associated with decreased severe RDS (odds ratio, 0.22; 95% confidence interval, 0.05-0.93; P < .05) and increased early-onset sepsis (odds ratio, 2.22; 95% confidence interval, 1.02-4.83; P < .05). Conclusion: In a prospective cohort of preterm infants, multivariable analyses reveal only a modest association between histologic chorioamnionitis and neonatal outcome.
AB - Objective: The objective of the study was to study the effects of histologic chorioamnionitis (HC) with or without fetal involvement and antenatal steroid (AS) exposure on neonatal outcome in a prospective cohort of preterm infants. Study Design: The clinical characteristics and placental histology were prospectively collected in 301 infants born at a gestational age 32.0 weeks or less in the Erasmus University Medical Center. Results: In univariable analyses, HC without fetal involvement (n = 53) was associated with decreased severe respiratory distress syndrome (RDS) (11% vs 28%; P < .05), whereas HC with fetal involvement infants (n = 68) had more necrotizing enterocolitis (9% vs 2%; P < .05), intraventricular hemorrhage (IVH) (25% vs 12%; P < .05), and neonatal mortality (19% vs 9%; P < .05). In HC without fetal involvement infants, AS reduced the incidences of RDS (43% vs 85%; P < .05) and IVH (5% vs 39%; P < .01). In multivariable analyses, HC without fetal involvement was associated with decreased severe RDS (odds ratio, 0.22; 95% confidence interval, 0.05-0.93; P < .05) and increased early-onset sepsis (odds ratio, 2.22; 95% confidence interval, 1.02-4.83; P < .05). Conclusion: In a prospective cohort of preterm infants, multivariable analyses reveal only a modest association between histologic chorioamnionitis and neonatal outcome.
KW - antenatal steroids
KW - chorioamnionitis
KW - fetal inflammation
KW - neonatal outcome
KW - preterm infants
UR - https://www.scopus.com/pages/publications/70749152791
U2 - 10.1016/j.ajog.2009.06.025
DO - 10.1016/j.ajog.2009.06.025
M3 - Article
C2 - 19729143
AN - SCOPUS:70749152791
SN - 0002-9378
VL - 201
SP - 587.e1-587.e8
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 6
ER -