HMG box containing transcription factors in lymphocyte differentiation

Marco W. Schilham, Hans Clevers

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

47 Citaten (Scopus)


The identifcation of the mammalian sex-determining gene Sry has led to the discovery of a large family of related ('HMG box') transcription factors that control developmental events in yeast, C. elegans, Drosophila and vertebrates. In lymphocyte differentiation, several HMG box proteins play a decisive role. Sox-4 is important for very early B-cell differentiation, while TCF-1/LEF-1 play a crucial role in early thymocyte development. TCF/LEF proteins have recently been found to constitute a downstream component of the Wingless/Wnt signal transduction pathway. In flies, this pathway controls segment polarity; in Xenopus it controls the definition of the body axis. Deregulation of the pathway occurs in several human tumors. These insights in the molecular events that are involved in TCF/LEF function in these organisms may eventually lead to the under standing of the function of these HMG box proteins in lymphoid development.

Originele taal-2Engels
Pagina's (van-tot)127-132
Aantal pagina's6
TijdschriftSeminars in Immunology
Nummer van het tijdschrift2
StatusGepubliceerd - apr. 1998
Extern gepubliceerdJa


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