Houdingsafhankelijke hoofdpijn door spontane intracraniële hypotensie

Mirjam E. Belderbos, G. J. Amelink, Jan Willem Dankbaar, F. H.H. Linn

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review


A 36-year-old woman presented with a 3-4 month history of severe, progressive headache. The headache was characterized by postural variation, with excruciating headache in the upright position and near-immediate relief upon recumbence. There was no history of trauma or lumbar puncture. Gadolineum-enhanced brain MRI revealed abnormalities characteristic intracranial hypotension. Spinal MRI showed a longitudinal extradural fluid collection; a localization of the dural defect was not found. The patient was treated with caffeine, bed rest and lumbar epidural blood patches; she recovered completely. Severe orthostatic headache which aggravates upon standing and is relieved by recumbence, can be caused by spontaneous intracranial hypotension. Recognition of its characteristic symptoms is needed for timely referral. Treatment is usually successful and can prevent life-threatening complications.

Vertaalde titel van de bijdragePosture-dependent headache caused by spontaneous intracranial hypotension
Originele taal-2Nederlands
TijdschriftNederlands Tijdschrift voor Geneeskunde
Nummer van het tijdschrift15
StatusGepubliceerd - 1 apr. 2021


  • Adult
  • Female
  • Headache/diagnosis
  • Humans
  • Intracranial Hypotension/complications
  • Magnetic Resonance Imaging/methods
  • Posture


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