Human-Derived Model Systems in Gynecological Cancer Research

Kadi Lõhmussaar, Matteo Boretto, Hans Clevers

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

23 Citaten (Scopus)


The human female reproductive tract (FRT) is a complex system that combines series of organs, including ovaries, fallopian tubes, uterus, cervix, vagina, and vulva; each of which possesses unique cellular characteristics and functions. This versatility, in turn, allows for the development of a wide range of epithelial gynecological cancers with distinct features. Thus, reliable model systems are required to better understand the diverse mechanisms involved in the regional pathogenesis of the reproductive tract and improve treatment strategies. Here, we review the current human-derived model systems available to study the multitude of gynecological cancers, including ovarian, endometrial, cervical, vaginal, and vulvar cancer, and the recent advances in the push towards personalized therapy.

Originele taal-2Engels
Pagina's (van-tot)1031-1043
Aantal pagina's13
TijdschriftTrends in Cancer
Nummer van het tijdschrift12
StatusGepubliceerd - dec. 2020
Extern gepubliceerdJa


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