TY - JOUR
T1 - Human papillomavirus, lichen sclerosus, and squamous cell carcinoma of the vulva
T2 - Detection and prognostic significance
AU - Ansink, Anca C.
AU - Krul, Mark R.L.
AU - De Weger, Roel A.
AU - Kleyne, John A.F.W.
AU - Pijpers, Helga
AU - Van Tinteren, Harm
AU - De Kraker, Elly W.
AU - Helmerhorst, Theo J.M.
AU - Heintz, A. Peter M.
PY - 1994/2
Y1 - 1994/2
N2 - Detection of HPV-DNA in squamous vulvar carcinoma, its prognostic significance, and investigation of the presence of lichen sclerosus near HPV- DNA-positive vulvar carcinomas were the objectives of this study. In 60 samples of squamous vulvar cancer, we looked for HPV-DNA by means of PCR. The same samples were examined for the presence of lichen sclerosus. The possible prognostic significance of the presence of HPV-DNA and lichen sclerosus was studied. Nineteen (32%) of the samples were HPV-DNA positive using PCR. Patients with an HPV-positive tumor had a better prognosis than those with an HPV-negative tumor (P = 0.03). Lichen sclerosus was found in 19 tumor samples, of which 7 had detectable HPV-DNA. Only a minority of vulvar cancers contain HPV-DNA. In contrast to previous statements, near some of these HPV- positive cancers, lichen sclerosus can be found.
AB - Detection of HPV-DNA in squamous vulvar carcinoma, its prognostic significance, and investigation of the presence of lichen sclerosus near HPV- DNA-positive vulvar carcinomas were the objectives of this study. In 60 samples of squamous vulvar cancer, we looked for HPV-DNA by means of PCR. The same samples were examined for the presence of lichen sclerosus. The possible prognostic significance of the presence of HPV-DNA and lichen sclerosus was studied. Nineteen (32%) of the samples were HPV-DNA positive using PCR. Patients with an HPV-positive tumor had a better prognosis than those with an HPV-negative tumor (P = 0.03). Lichen sclerosus was found in 19 tumor samples, of which 7 had detectable HPV-DNA. Only a minority of vulvar cancers contain HPV-DNA. In contrast to previous statements, near some of these HPV- positive cancers, lichen sclerosus can be found.
UR - http://www.scopus.com/inward/record.url?scp=0028118382&partnerID=8YFLogxK
U2 - 10.1006/gyno.1994.1028
DO - 10.1006/gyno.1994.1028
M3 - Article
AN - SCOPUS:0028118382
SN - 0090-8258
VL - 52
SP - 180
EP - 184
JO - Gynecologic Oncology
JF - Gynecologic Oncology
IS - 2
ER -