Hydrophobic patches on protein subunit interfaces: Characteristics and prediction

Philip Lijnzaad, Patrick Argos

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

102 Citaten (Scopus)

Samenvatting

Hydrophobic patches, defined as clusters of neighboring apolar atoms deemed accessible on a given protein surface, have been investigated on protein subunit interfaces. The data were taken from known tertiary structures of multimeric protein complexes. Amino acid composition and preference, patch size distribution, and patch contact complementarity across associating subunits were examined and compared with hydrophobic patches found on the solvent-accessible surface of the multimeric complexes. The largest or second largest patch on the accessible surface of the entire subunit was involved in multimeric interfaces in 90% of the cases. These results should prove useful for subunit design and engineering as well as for prediction of subunit interface regions.

Originele taal-2Engels
Pagina's (van-tot)333-343
Aantal pagina's11
TijdschriftProteins: Structure, Function and Genetics
Volume28
Nummer van het tijdschrift3
DOI's
StatusGepubliceerd - 1997
Extern gepubliceerdJa

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