Hypothalamic-Pituitary Outcome after Treatment for Childhood Craniopharyngioma

Jiska van Schaik, Eelco W Hoving, Hermann L Müller, Hanneke M van Santen

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

8 Citaten (Scopus)


Although childhood-onset craniopharyngioma is a low-grade intracranial tumor with excellent prognosis in terms of overall survival, survivors may suffer from devastating consequences caused by hypothalamic damage. Disease- or treatment-related hypothalamic damage leads to disturbed hunger-satiety and thirst feelings, decreased energy expenditure, behavioral problems, disturbances of circadian rhythm, temperature dysregulation, and pituitary dysfunction. These children are at great risk for developing the metabolic syndrome and comorbidities leading to premature mortality. In this chapter, we shall discuss hypothalamic-pituitary morbidity and outcome of childhood-onset craniopharyngioma patients and future perspectives for improvement.

Originele taal-2Engels
Pagina's (van-tot)47-57
Aantal pagina's11
TijdschriftFrontiers of hormone research
StatusGepubliceerd - 2021


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