Hypothalamic syndrome

Hermann L. Müller, Maithé Tauber, Elizabeth A. Lawson, Jale Özyurt, Brigitte Bison, Juan Pedro Martinez-Barbera, Stephanie Puget, Thomas E. Merchant, Hanneke M. van Santen

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

63 Citaten (Scopus)

Samenvatting

Hypothalamic syndrome (HS) is a rare disorder caused by disease-related and/or treatment-related injury to the hypothalamus, most commonly associated with rare, non-cancerous parasellar masses, such as craniopharyngiomas, germ cell tumours, gliomas, cysts of Rathke's pouch and Langerhans cell histiocytosis, as well as with genetic neurodevelopmental syndromes, such as Prader-Willi syndrome and septo-optic dysplasia. HS is characterized by intractable weight gain associated with severe morbid obesity, multiple endocrine abnormalities and memory impairment, attention deficit and reduced impulse control as well as increased risk of cardiovascular and metabolic disorders. Currently, there is no cure for this condition but treatments for general obesity are often used in patients with HS, including surgery, medication and counselling. However, these are mostly ineffective and no medications that are specifically approved for the treatment of HS are available. Specific challenges in HS are because the syndrome represents an adverse effect of different diseases, and that diagnostic criteria, aetiology, pathogenesis and management of HS are not completely defined.

Originele taal-2Engels
Pagina's (van-tot)24
Aantal pagina's1
TijdschriftNature reviews. Disease primers
Volume8
Nummer van het tijdschrift1
DOI's
StatusGepubliceerd - 21 apr. 2022

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