Samenvatting
Immunotherapy with tumor-specific peptide-loaded dendritic cells represents a promising therapeutic approach for patients with multifocal primary or early relapsed Ewing family tumors (EFT). The authors therefore screened a peptide library derived from the fusion region of the EFT-specific chimeric transcription factor EWS-FLI1 for immunogenic peptides. T-cell priming with 10 peptides was evaluated using IFNγ video-assisted automated enzyme-linked immunospot technique. The authors report the identification of the first EFT-specific immunogenic T-cell epitope so far. Its identification will lead to a better understanding of EFT immunology and may improve DC-based immunotherapy.
Originele taal-2 | Engels |
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Pagina's (van-tot) | 297-308 |
Aantal pagina's | 12 |
Tijdschrift | Pediatric Hematology and Oncology |
Volume | 22 |
Nummer van het tijdschrift | 4 |
DOI's | |
Status | Gepubliceerd - jun. 2005 |
Extern gepubliceerd | Ja |