Identification of subgroups of high-grade oligodendroglial tumors by comparative genomic hybridization

Judith W.M. Jeuken, Sandra H.E. Sprenger, Pieter Wesseling, Merryn V.E. Macville, Andreas Von Deimling, Hans L.J.M. Teepen, Jacobus J. Van Overbeeke, Rudolf H. Boerman

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

90 Citaten (Scopus)


In contrast to astrocytic tumors, approximately two thirds of anaplastic oligodendrogliomas are reported to be chemosensitive. Relatively little is known about the genetic aberrations in oligodendroglial tumors (OTs). In order to elucidate oligodendroglial oncogenesis and to find specific genetic aberrations that may have prognostic and therapeutic implications, we performed comparative genomic hybridization (CGH) to detect chromosomal copy number changes in 17 low-grade OTs (LG-OTs) and 12 high-grade OTs (HG-OTs) lacking a prominent astrocytic component. Loss of chromosome 1p (79%) and 19q (76%) were most frequently detected by CGH, all LG-OTs and 50% of the HG-OTs contained -1p (including 1p36-32). -19q (including 19q13.3), or both, and the rest of the HG-OTs showed +7, -10, or both. Since losses of 1p36-32 and 19q13.3 were mutually exclusive with +7 or - 10, the HG-OTs could be divided in -1p/-19q and +7/-10 tumors. While the -1p/-19q tumors can be considered as pure anaplastic oligodendrogliomas, the +7/-10 tumors may rather be glioblastomas with prominent oligodendroglial differentiation. We conclude that CGH is a powerful tool to assist in the identification of 2 major subgroups of HG-OTs with prognostic and possibly therapeutic relevance.

Originele taal-2Engels
Pagina's (van-tot)606-612
Aantal pagina's7
TijdschriftJournal of Neuropathology and Experimental Neurology
Nummer van het tijdschrift6
StatusGepubliceerd - jun. 1999
Extern gepubliceerdJa


Duik in de onderzoeksthema's van 'Identification of subgroups of high-grade oligodendroglial tumors by comparative genomic hybridization'. Samen vormen ze een unieke vingerafdruk.

Citeer dit