TY - JOUR
T1 - Identifying the research, advocacy, policy and implementation needs for the prevention and management of respiratory syncytial virus lower respiratory tract infection in low- and middle-income countries
AU - Carbonell-Estrany, Xavier
AU - Simões, Eric A.F.
AU - Bont, Louis J.
AU - Gentile, Angela
AU - Homaira, Nusrat
AU - Scotta, Marcelo Comerlato
AU - Stein, Renato T.
AU - Torres, Juan P.
AU - Sheikh, Jarju
AU - Broor, Shobha
AU - Khuri-Bulos, Najwa
AU - Nokes, D. James
AU - Munywoki, Patrick K.
AU - Bassat, Quique
AU - Sharma, Arun K.
AU - Basnet, Sudha
AU - Garba, Maria
AU - De Jesus-Cornejo, Joanne
AU - Lupisan, Socorro P.
AU - Nunes, Marta C.
AU - Divarathna, Maduja
AU - Fullarton, John R.
AU - Rodgers-Gray, Barry S.
AU - Keary, Ian
AU - Reñosa, Mark Donald C.
AU - Verwey, Charl
AU - Moore, David P.
AU - Noordeen, Faseeha
AU - Kabra, Sushil
AU - do Vale, Marynéa Silva
AU - Paternina-De La Ossa, Rolando
AU - Mariño, Cristina
AU - Figueras-Aloy, Josep
AU - Krilov, Leonard
AU - Berezin, Eitan
AU - Zar, Heather J.
AU - Paudel, Krishna
AU - Safadi, Marco Aurelio Palazzi
AU - Dbaibo, Ghassan
AU - Jroundi, Imane
AU - Jha, Runa
AU - Rafeek, Rukshan A.M.
AU - Pinheiro, Rossiclei de Souza
AU - Bracht, Marianne
AU - Muthugala, Rohitha
AU - Lanari, Marcello
AU - Martinón-Torres, Federico
AU - Mitchell, Ian
AU - Irimu, Grace
AU - Pandey, Apsara
AU - Krishnan, Anand
AU - Mejias, Asuncion
AU - da Costa, Marcela Santos Corrêa
AU - Shrestha, Shrijana
AU - Pernica, Jeffrey M.
AU - de Carvalho, Felipe Cotrim
AU - Jalango, Rose E.
AU - Ibrahim, Hafsat
AU - Ewa, Atana
AU - Ensinck, Gabriela
AU - Ulloa-Gutierrez, Rolando
AU - Miralha, Alexandre Lopes
AU - Lucion, Maria Florencia
AU - Hassan, Md Zakiul
AU - Akhtar, Zubair
AU - Aleem, Mohammad Abdul
AU - Chowdhury, Fahmida
AU - Rojo, Pablo
AU - Sande, Charles
AU - Musau, Abednego
AU - Zaman, Khalequ
AU - Helena, Luiza
AU - Arlant, Falleiros
AU - Ghimire, Prakash
AU - Price, April
AU - Subedi, Kalpana Upadhyay
AU - Brenes-Chacon, Helena
AU - Goswami, Doli Rani
AU - Rahman, Mohammed Ziaur
AU - Hossain, Mohammad Enayet
AU - Chisti, Mohammod Jobayer
AU - Vain, Nestor E.
AU - Lim, Audrey
AU - Chiu, Aaron
AU - Papenburg, Jesse
AU - Juarez, Maria del Valle
AU - Senaratne, Thamarasi
AU - Arunasalam, Shiyamalee
AU - Strand, Tor A.
AU - Ayuk, Adaeze
AU - Ogunrinde, Olufemi
AU - Tavares, Lohanna Valeska de Sousa
AU - Garba, Comfort
AU - Garba, Bilkisu I.
AU - Dawa, Jeanette
AU - Gordon, Michelle
AU - Osoro, Eric
AU - Agoti, Charles N.
AU - Nyawanda, Bryan
AU - Ngama, Mwanajuma
AU - Tabu, Collins
AU - Mathew, Joseph L.
AU - Cornacchia, Andrew
AU - Rai, Ganesh Kumar
AU - Jain, Amita
AU - Giongo, Mateus Sfoggia
AU - Paes, Bosco A.
N1 - © 2022 Carbonell-Estrany, Simões, Bont, Gentile, Homaira, Scotta, Stein, Torres, Sheikh, Broor, Khuri-Bulos, Nokes, Munywoki, Bassat, Sharma, Basnet, Garba, De Jesus-Cornejo, Lupisan, Nunes, Divarathna, Fullarton, Rodgers-Gray, Keary, Reñosa, Verwey, Moore, Noordeen, Kabra, do Vale, Paternina-De La Ossa, Mariño, Figueras-Aloy, Krilov, Berezin, Zar, Paudel, Safadi, Dbaibo, Jroundi, Jha, Rafeek, Pinheiro, Bracht, Muthugala, Lanari, Martinón-Torres, Mitchell, Irimu, Pandey, Krishnan, Mejias, Santos Corrêa Da Costa, Shrestha, Pernica, Cotrim de Carvalho, Jalango, Ibrahim, Ewa, Ensinck, Ulloa-Gutierrez, Miralha, Lucion, Hassan, Akhtar, Aleem, Chowdhury, Rojo, Sande, Musau, Zaman, Arlant, Ghimire, Price, Subedi, Brenes-Chacon, Goswami, Rahman, Hossain, Chisti, Vain, Lim, Chiu, Papenburg, Juarez, Senaratne, Arunasalam, Strand, Ayuk, Ogunrinde, Tavares, Garba, Garba, Dawa, Gordon, Osoro, Agoti, Nyawanda, Ngama, Tabu, Mathew, Cornacchia, Rai, Jain, Giongo and Paes.
PY - 2022/11/9
Y1 - 2022/11/9
N2 - Introduction: The high burden of respiratory syncytial virus (RSV) infection in young children disproportionately occurs in low- and middle-income countries (LMICs). The PROUD (Preventing RespiratOry syncytial virUs in unDerdeveloped countries) Taskforce of 24 RSV worldwide experts assessed key needs for RSV prevention in LMICs, including vaccine and newer preventive measures. Methods: A global, survey-based study was undertaken in 2021. An online questionnaire was developed following three meetings of the Taskforce panellists wherein factors related to RSV infection, its prevention and management were identified using iterative questioning. Each factor was scored, by non-panellists interested in RSV, on a scale of zero (very-low-relevance) to 100 (very-high-relevance) within two scenarios: (1) Current and (2) Future expectations for RSV management. Results: Ninety questionnaires were completed: 70 by respondents (71.4% physicians; 27.1% researchers/scientists) from 16 LMICs and 20 from nine high-income (HI) countries (90.0% physicians; 5.0% researchers/scientists), as a reference group. Within LMICs, RSV awareness was perceived to be low, and management was not prioritised. Of the 100 factors scored, those related to improved diagnosis particularly access to affordable point-of-care diagnostics, disease burden data generation, clinical and general education, prompt access to new interventions, and engagement with policymakers/payers were identified of paramount importance. There was a strong need for clinical education and local data generation in the lowest economies, whereas upper-middle income countries were more closely aligned with HI countries in terms of current RSV service provision. Conclusion: Seven key actions for improving RSV prevention and management in LMICs are proposed.
AB - Introduction: The high burden of respiratory syncytial virus (RSV) infection in young children disproportionately occurs in low- and middle-income countries (LMICs). The PROUD (Preventing RespiratOry syncytial virUs in unDerdeveloped countries) Taskforce of 24 RSV worldwide experts assessed key needs for RSV prevention in LMICs, including vaccine and newer preventive measures. Methods: A global, survey-based study was undertaken in 2021. An online questionnaire was developed following three meetings of the Taskforce panellists wherein factors related to RSV infection, its prevention and management were identified using iterative questioning. Each factor was scored, by non-panellists interested in RSV, on a scale of zero (very-low-relevance) to 100 (very-high-relevance) within two scenarios: (1) Current and (2) Future expectations for RSV management. Results: Ninety questionnaires were completed: 70 by respondents (71.4% physicians; 27.1% researchers/scientists) from 16 LMICs and 20 from nine high-income (HI) countries (90.0% physicians; 5.0% researchers/scientists), as a reference group. Within LMICs, RSV awareness was perceived to be low, and management was not prioritised. Of the 100 factors scored, those related to improved diagnosis particularly access to affordable point-of-care diagnostics, disease burden data generation, clinical and general education, prompt access to new interventions, and engagement with policymakers/payers were identified of paramount importance. There was a strong need for clinical education and local data generation in the lowest economies, whereas upper-middle income countries were more closely aligned with HI countries in terms of current RSV service provision. Conclusion: Seven key actions for improving RSV prevention and management in LMICs are proposed.
KW - burden
KW - decision research
KW - developing countries
KW - diagnostics
KW - management
KW - prevention
KW - RSV
UR - http://www.scopus.com/inward/record.url?scp=85142930523&partnerID=8YFLogxK
U2 - 10.3389/fped.2022.1033125
DO - 10.3389/fped.2022.1033125
M3 - Article
C2 - 36440349
AN - SCOPUS:85142930523
SN - 2296-2360
VL - 10
SP - 1033125
JO - Frontiers in Pediatrics
JF - Frontiers in Pediatrics
M1 - 1033125
ER -