IFN-λ-mediated IL-12 production in macrophages induces IFN-γ production in human NK cells

Rik A. de Groen, Arjan Boltjes, Jun Hou, Bi Sheng Liu, Fiona Mcphee, Jacques Friborg, Harry L.A. Janssen, André Boonstra

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

56 Citaten (Scopus)


With increasing interest in alternative options to interferon-alpha-based treatments, IFN-λ has shown therapeutic promise in a variety of diseases. Although the antiviral activity of IFN-λ has been extensively studied, there is limited knowledge regarding the immunological functions of IFN-λ and how these differ from those of other classes of IFNs. In this study, we investigated the effects of IFN-λ on primary human NK cells, both in a direct and indirect capacity. We demonstrate that in contrast to interferon-alpha, IFN-λ is unable to directly stimulate NK cells, due to the absence of IFN-λ receptor chain 1 (IFN-λR1) on NK cells. However, IFN-λ, in combination with TLR4 challenge, is able to induce the production of select members of the IL-12 family of cytokines in monocyte-derived macrophages. We further show that through macrophage-mediated IL-12 production, IFN-λ is able to indirectly affect NK cells and ultimately induce IFN-γ production.

Originele taal-2Engels
Pagina's (van-tot)250-259
Aantal pagina's10
TijdschriftEuropean Journal of Immunology
Nummer van het tijdschrift1
StatusGepubliceerd - 1 jan. 2015
Extern gepubliceerdJa


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