TY - JOUR
T1 - Immunostimulation versus immunosuppression after multiple vaccinations
T2 - The woes of therapeutic vaccine development
AU - Eggermont, Alexander M.M.
PY - 2009/11/15
Y1 - 2009/11/15
N2 - Three articles in this issue of Clinical Cancer Research show how multiple vaccinations can lead to immunosuppression. Moreover, two studies in patients show that granulocyte macrophage colony-stimulating factor (GM-CSF) as an adjuvant immunostimulant to different kind of vaccines can lead to adverse outcome in terms of relapse-free and overall survival. Modulation of regulatory T-cell activity may be required to overcome this outcome and may be crucial for the successful development of therapeutic vaccines.
AB - Three articles in this issue of Clinical Cancer Research show how multiple vaccinations can lead to immunosuppression. Moreover, two studies in patients show that granulocyte macrophage colony-stimulating factor (GM-CSF) as an adjuvant immunostimulant to different kind of vaccines can lead to adverse outcome in terms of relapse-free and overall survival. Modulation of regulatory T-cell activity may be required to overcome this outcome and may be crucial for the successful development of therapeutic vaccines.
UR - http://www.scopus.com/inward/record.url?scp=72549108633&partnerID=8YFLogxK
U2 - 10.1158/1078-0432.CCR-09-2377
DO - 10.1158/1078-0432.CCR-09-2377
M3 - Comment/debate
C2 - 19903779
AN - SCOPUS:72549108633
SN - 1078-0432
VL - 15
SP - 6745
EP - 6747
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 22
ER -