Impaired neutralising antibody formation and high transduction efficacy after isolated hepatic perfusion with adenoviral vectors

B. Van Etten; A. M.M. Eggermont; G. Ambagtsheer; S. T. Van Tiel; T. L.M. Ten Hagen

doi:10.1038/sj.bjc.6602151

Impaired neutralising antibody formation and high transduction efficacy after isolated hepatic perfusion with adenoviral vectors

B. Van Etten, A. M.M. Eggermont, G. Ambagtsheer, S. T. Van Tiel, T. L.M. Ten Hagen

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

3 Citaten (Scopus)

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Local adenoviral gene transfer can be performed by means of isolated hepatic perfusion (IHP). This methodology is a very effective and safe way to deliver adenoviral vectors. We studied the immune response after IHP, A decreased neutralising antibody formation was observed, offering possibilities for further research in the field of gene therapy in isolated perfusion settings.

Originele taal-2	Engels
Pagina's (van-tot)	1610-1613
Aantal pagina's	4
Tijdschrift	British Journal of Cancer
Volume	91
Nummer van het tijdschrift	8
DOI's	https://doi.org/10.1038/sj.bjc.6602151
Status	Gepubliceerd - 18 okt. 2004
Extern gepubliceerd	Ja

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title = "Impaired neutralising antibody formation and high transduction efficacy after isolated hepatic perfusion with adenoviral vectors",

abstract = "Local adenoviral gene transfer can be performed by means of isolated hepatic perfusion (IHP). This methodology is a very effective and safe way to deliver adenoviral vectors. We studied the immune response after IHP, A decreased neutralising antibody formation was observed, offering possibilities for further research in the field of gene therapy in isolated perfusion settings.",

keywords = "Adenovirus, Antibodies, Gene therapy, Liver perfusion",

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AU - Van Tiel, S. T.

AU - Ten Hagen, T. L.M.

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AB - Local adenoviral gene transfer can be performed by means of isolated hepatic perfusion (IHP). This methodology is a very effective and safe way to deliver adenoviral vectors. We studied the immune response after IHP, A decreased neutralising antibody formation was observed, offering possibilities for further research in the field of gene therapy in isolated perfusion settings.

KW - Adenovirus

KW - Antibodies

KW - Gene therapy

KW - Liver perfusion

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Impaired neutralising antibody formation and high transduction efficacy after isolated hepatic perfusion with adenoviral vectors

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