Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals

Keyphrases

• Mutagenesis 100%
• Mismatch Repair 100%
• Gene Knockout 100%
• N-ethyl-N-nitrosourea 80%
• Genetic Background 40%
• Germline mutation 20%
• MSH6 20%
• DNA Damage 20%
• High-throughput 20%
• Mutation Rate 20%
• Genetic Model 20%
• Mutation Spectrum 20%
• Rattus Norvegicus 20%
• Knockout Rat 20%
• Pharmacological Studies 20%
• Animal Use 20%
• Laboratory Mice 20%
• Knockdown Efficiency 20%
• Screening Cost 20%
• Preferred Models 20%
• Amino Acid Variation 20%
• Molecular mutations 20%
• Physiological Research 20%
• Mutation Discovery 20%
• Efficiency Improvement 20%
• Mutagenesis Approaches 20%

Biochemistry, Genetics and Molecular Biology

• DNA Mismatch Repair 100%
• Mutagenesis 100%
• Rat 100%
• Genetic Background 40%
• Amino Acids 20%
• Germline Mutation 20%
• Allele 20%
• DNA Damage 20%
• Mutation Rate 20%
• Genetic Model 20%
• Rattus norvegicus 20%
• Knockout Rat 20%
• Experimental Rat 20%

Immunology and Microbiology

• Mutagenesis 100%
• Mismatch Repair 100%
• Rat 100%
• Genetic Background 40%
• Allele 20%
• DNA Damage 20%
• Germline Mutation 20%
• Mutation Rate 20%
• Experimental Rat 20%
• Knockout Rat 20%
• Rattus norvegicus 20%
• Amino Acid 20%