In-depth Characterization of Vaccine Breakthrough Infections with SARS-CoV-2 among Health Care Workers in a Dutch Academic Medical Center

Lidewij W. Rümke, Femke C. Groenveld, Yvonne M.G. Van Os, Patrique Praest, Anniek A.N. Tanja, Dorien T.C.M. De Jong, Jori Symons, Rob Schuurman, Tessa Reinders, L. Marije Hofstra, Stefan Nierkens, Steven F.T. Thijsen, Michiel Heron, Robert Jan Lebbink, Jeffrey M. Beekman, Monique Nijhuis, Annemarie M.J. Wensing

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

2 Citaten (Scopus)

Samenvatting

Severe acute respiratory syndrome coronavirus 2 infection after coronavirus disease 2019 vaccination raises concerns about the emergence of vaccine escape variants. Here we characterize 14 breakthrough infections among 5860 fully vaccinated Dutch health care workers ≥14 days after the final dose of vaccination with either BNT162b2, mRNA-1273, or Ad26.COV2.S. These breakthrough infections presented with regular B.1.1.7 (Alpha) and B.1.617.2 (Delta) variants and high viral loads, despite normal vaccine-induced B- and T-cell immune responses detected by live virus neutralization assays and ELISpot. High-risk exposure settings, such as in households, indicate a potential risk of viral transmission despite full vaccination.

Originele taal-2Engels
Artikelnummerofab553
TijdschriftOpen Forum Infectious Diseases
Volume9
Nummer van het tijdschrift1
DOI's
StatusGepubliceerd - 1 jan. 2022
Extern gepubliceerdJa

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