Incidence, severity and outcome of central line related complications in pediatric oncology patients; A single center study

Ceder van den Bosch, Tjomme van der Bruggen, Florine Frakking, Cecilia Terwisscha van Scheltinga, Cornelis P van de Ven, Martine van Grotel, Lianne Wellens, Yvette Loeffen, Marta Fiocco, Marc Wijnen

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

27 Citaten (Scopus)


Background: Central venous access device (CVAD)-related complications are associated with high morbidity rates. This study was performed to underline the importance of CVAD-complication prevention and treatment. Methods: An audit of practice of CVAD-related complications in pediatric oncology patients receiving a CVAD between January 2015 and June 2017 was performed. CVADs included were totally implantable venous access ports (TIVAPs), Hickman–Broviac® (HB), nontunneled, and peripherally inserted CVADs. Results: A total of 201 children, with 307 CVADs, were analyzed. The incidence rates per 1000 CVAD-days for the most common complications were 1.66 for malfunctions, and 1.51 for central line-associated bloodstream infections (CLABSIs). Of all CVADs inserted, 37.1% were removed owing to complications, of which 45.6% were owing to CLABSIs. In 42% of the CLABSIs, the CLABSI could be successfully cured with systemic antibiotic treatment only. Of all included patients, 5.0% were admitted to the intensive care unit owing to CLABSI. The HB-CVAD compared to the TIVAP was a risk factor for CVAD-related complications, CLABSIs and dislocations in particular. Conclusions: The incidence of CVAD-related complications is high. Research on the prevention and treatment of CVAD-related complications in pediatric oncology patients should be a high priority for all health care professionals. Type of study: Prognosis study (retrospective). Level of evidence: Level II.

Originele taal-2Nederlands
Pagina's (van-tot)1894-1900
Aantal pagina's7
TijdschriftJournal of Pediatric Surgery
Nummer van het tijdschrift9
StatusGepubliceerd - 2019

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