Incorporation of concentration data below the limit of quantification in population pharmacokinetic analyses

Keyphrases

• Limit of Quantification 100%
• Concentration Data 100%
• Population Pharmacokinetic Analysis 100%
• Population Pharmacokinetics (PopPK) 25%
• Parameter Estimation 16%
• Superior Performance 16%
• Real Population 16%
• Pharmacokinetic Data 8%
• Root Mean Square Error 8%
• Covariance 8%
• Quantification Method 8%
• Analytical Validation 8%
• Simulation Analysis 8%
• Method Analysis 8%
• Error Value 8%
• Analytical Error Model 8%
• Residual Error Model 8%
• Similar Parameter 8%
• Model Misspecification 8%
• Relative Root Mean Square Error (RRMSE) 8%
• Quantification Approaches 8%

Mathematics

• Lower Limit 100%
• Mean Square Error 50%
• Residuals 25%
• Parameter Estimation 25%
• Likelihood 25%
• Model Misspecification 25%
• Parameter Estimate 25%
• Covariance 25%

Agricultural and Biological Sciences

• Pharmacokinetics 100%
• Covariance 16%
• Likelihood 16%