Increased risk of respiratory tract infections in children with Down syndrome: The consequence of an altered immune system

Beatrijs L.P. Bloemers; Chantal J.M. Broers; Louis Bont; Michel E. Weijerman; Reinoud J.B.J. Gemke; A. Marceline van Furth

doi:10.1016/j.micinf.2010.05.007

Increased risk of respiratory tract infections in children with Down syndrome: The consequence of an altered immune system

Beatrijs L.P. Bloemers
, Chantal J.M. Broers
, Louis Bont
, Michel E. Weijerman
, Reinoud J.B.J. Gemke
, A. Marceline van Furth

Onderzoeksoutput: Bijdrage aan tijdschrift › Kort overzicht › peer review

96 Citaten (Scopus)

Samenvatting

Down syndrome (DS) is the most common chromosomal abnormality among live-born infants. Respiratory tract infections are the most important cause of mortality in individuals with DS at all ages. In recent decades several studies have been performed to elucidate abnormalities of the immune system in DS. However, the influence of the immune system on the occurrence of respiratory tract infections in these children has never been reviewed.

Originele taal-2	Engels
Pagina's (van-tot)	799-808
Aantal pagina's	10
Tijdschrift	Microbes and Infection
Volume	12
Nummer van het tijdschrift	11
DOI's	https://doi.org/10.1016/j.micinf.2010.05.007
Status	Gepubliceerd - okt. 2010
Extern gepubliceerd	Ja

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10.1016/j.micinf.2010.05.007

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title = "Increased risk of respiratory tract infections in children with Down syndrome: The consequence of an altered immune system",

abstract = "Down syndrome (DS) is the most common chromosomal abnormality among live-born infants. Respiratory tract infections are the most important cause of mortality in individuals with DS at all ages. In recent decades several studies have been performed to elucidate abnormalities of the immune system in DS. However, the influence of the immune system on the occurrence of respiratory tract infections in these children has never been reviewed.",

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author = "Bloemers, \{Beatrijs L.P.\} and Broers, \{Chantal J.M.\} and Louis Bont and Weijerman, \{Michel E.\} and Gemke, \{Reinoud J.B.J.\} and \{van Furth\}, \{A. Marceline\}",

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T2 - The consequence of an altered immune system

AU - Bloemers, Beatrijs L.P.

AU - Broers, Chantal J.M.

AU - Bont, Louis

AU - Weijerman, Michel E.

AU - Gemke, Reinoud J.B.J.

AU - van Furth, A. Marceline

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AB - Down syndrome (DS) is the most common chromosomal abnormality among live-born infants. Respiratory tract infections are the most important cause of mortality in individuals with DS at all ages. In recent decades several studies have been performed to elucidate abnormalities of the immune system in DS. However, the influence of the immune system on the occurrence of respiratory tract infections in these children has never been reviewed.

KW - Adaptive immunity

KW - Down syndrome

KW - Immunology

KW - Innate immunity

KW - Respiratory tract infections

UR - https://www.scopus.com/pages/publications/77957749242

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M3 - Short survey

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ER -

Increased risk of respiratory tract infections in children with Down syndrome: The consequence of an altered immune system

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