Influence of co-medicated drugs on the biotransformation of ThioTEPA to TEPA and ThioTEPA-mercapturate

Keyphrases

• Thiotepa 100%
• Mercapturates 100%
• Biotransformation 100%
• Cyclophosphamide 40%
• Carboplatin 20%
• Metabolism 20%
• Amphotericin B 20%
• Ondansetron 20%
• Itraconazol 20%
• Clinically Significant 10%
• Germ Cell Tumor 10%
• Drug Interactions 10%
• Anticancer Drugs 10%
• Platinum Drugs 10%
• Fluconazole 10%
• IC50 Value 10%
• Breast Cells 10%
• Incubation 10%
• Glutathione S-transferase 10%
• Glutathione 10%
• Lorazepam 10%
• Granisetron 10%
• Therapeutic Drug Levels 10%
• Bioactivation 10%
• Ranitidine 10%
• Aciclovir 10%
• Hepatic Metabolism 10%
• Cytochrome P450 Inhibitors 10%
• Unwanted Side Effects 10%
• Co-administered Drugs 10%
• Human Microsomes 10%
• Enzyme Inducer 10%
• P450 Substrates 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Thiotepa 100%
• TEPA 100%
• Cyclophosphamide 57%
• Carboplatin 28%
• Itraconazole 28%
• Glutathione 28%
• Zofran 28%
• Amphotericin B 28%
• Drug-Drug Interaction 14%
• Dexamethasone 14%
• Anticarcinogen 14%
• Side Effect 14%
• Fluconazole 14%
• IC50 14%
• Germ Cell Cancer 14%
• Transferase 14%
• Lorazepam 14%
• Granisetron 14%
• Ranitidine 14%
• Bioactivation 14%
• Aciclovir 14%
• Cytochrome P450 Inhibitor 14%