Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms

Chris S. Pridgeon, Constanze Schlott, Min Wei Wong, Minne B. Heringa, Tobias Heckel, Joe Leedale, Laurence Launay, Vitalina Gryshkova, Stefan Przyborski, Rachel N. Bearon, Emma L. Wilkinson, Tahera Ansari, John Greenman, Delilah F.G. Hendriks, Sue Gibbs, James Sidaway, Rowena L. Sison-Young, Paul Walker, Mike J. Cross, B. Kevin ParkChris E.P. Goldring

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

37 Citaten (Scopus)

Samenvatting

The development of improved, innovative models for the detection of toxicity of drugs, chemicals, or chemicals in cosmetics is crucial to efficiently bring new products safely to market in a cost-effective and timely manner. In addition, improvement in models to detect toxicity may reduce the incidence of unexpected post-marketing toxicity and reduce or eliminate the need for animal testing. The safety of novel products of the pharmaceutical, chemical, or cosmetics industry must be assured; therefore, toxicological properties need to be assessed. Accepted methods for gathering the information required by law for approval of substances are often animal methods. To reduce, refine, and replace animal testing, innovative organotypic in vitro models have emerged. Such models appear at different levels of complexity ranging from simpler, self-organized three-dimensional (3D) cell cultures up to more advanced scaffold-based co-cultures consisting of multiple cell types. This review provides an overview of recent developments in the field of toxicity testing with in vitro models for three major organ types: heart, skin, and liver. This review also examines regulatory aspects of such models in Europe and the UK, and summarizes best practices to facilitate the acceptance and appropriate use of advanced in vitro models.

Originele taal-2Engels
Pagina's (van-tot)557-569
Aantal pagina's13
TijdschriftArchives of Toxicology
Volume92
Nummer van het tijdschrift2
DOI's
StatusGepubliceerd - 1 feb. 2018
Extern gepubliceerdJa

Vingerafdruk

Duik in de onderzoeksthema's van 'Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms'. Samen vormen ze een unieke vingerafdruk.

Citeer dit