@article{44fcfefdb0a4437d9076f74edbc97800,
title = "Instability of human TATA-binding protein CAG triplet repeats during amplification by PCR",
abstract = "Polymerase chain reaction (PCR) of a TATA-binding protein cDNA that contains CAG triplet repeats results in heterogeneous products. This is caused by a variable loss in the number of CAG triplets. Sequence analysis of PCR products suggests that instability increases with repeat length.",
keywords = "Dynamic mutation, PCR, PCR instability, TATA-binding protein, Triplet repeat expansion",
author = "Holstege, {Frank C.P.} and {van der Vliet}, {Peter C.} and Timmers, {H. Th Marc}",
note = "Funding Information: We wish to thank Elly Holthuizen for oligonucleotide synthesis and Marian Walhout for critically reviewing this manuscript. The research of H.Th.M.T. was supported by a fellowship from the Royal Netherlands Academy of Arts and Sciences. This work was also supported in part by the Netherlands Foundation for Chemical Research (SON) and with financial support from the Netherlands Organization for Scientific Research (NWO).",
year = "1994",
month = sep,
day = "13",
doi = "10.1016/0167-4781(94)90260-7",
language = "English",
volume = "1219",
pages = "157--159",
journal = "BBA - Gene Structure and Expression",
issn = "0167-4781",
publisher = "Elsevier B.V.",
number = "1",
}