Integrated transcriptional analysis unveils the dynamics of cellular differentiation in the developing mouse hippocampus

Giovanni Iacono, Marco Benevento, Aline Dubos, Yann Herault, Hans Van Bokhoven, Nael Nadif Kasri, Hendrik G. Stunnenberg

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

6 Citaten (Scopus)

Samenvatting

The ability to assign expression patterns to the individual cell types that constitute a tissue is a major challenge. This especially applies to brain, given its plethora of different, functionally interconnected cell types. Here, we derived cell type-specific transcriptome signatures from existing single cell RNA data and integrated these signatures with a newly generated dataset of expression (bulk RNA-Seq) of the postnatal developing mouse hippocampus. This integrated analysis allowed us to provide a comprehensive and unbiased prediction of the differentiation drivers for 11 different hippocampal cell types and describe how the different cell types interact to support crucial developmental stages. Our results provide a reliable resource of predicted differentiation drivers and insights into the multifaceted aspects of the cells in hippocampus during development.

Originele taal-2Engels
Artikelnummer18073
TijdschriftScientific Reports
Volume7
Nummer van het tijdschrift1
DOI's
StatusGepubliceerd - 1 dec. 2017
Extern gepubliceerdJa

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