TY - JOUR
T1 - Interplay between TRP channels and the cytoskeleton in health and disease
AU - Clark, Kristopher
AU - Middelbeek, Jeroen
AU - van Leeuwen, Frank N
PY - 2008/9
Y1 - 2008/9
N2 - Transient receptor potential (TRP) channels are a family of cation channels that play a key role in ion homeostasis and cell volume regulation. In addition, TRP channels are considered universal integrators of sensory information required for taste, vision, hearing, touch, temperature, and the detection of mechanical force. Seminal investigations exploring the molecular mechanisms of phototransduction in Drosophila have demonstrated that TRP channels operate within macromolecular complexes closely associated with the cytoskeleton. More recent evidence shows that mammalian TRP channels similarly connect to the cytoskeleton to affect cytoskeletal organization and cell adhesion via ion-transport-dependent and -independent mechanisms. In this review, we discuss new insights into the interplay between TRP channels and the cytoskeleton and provide recent examples of such interactions in different physiological systems.
AB - Transient receptor potential (TRP) channels are a family of cation channels that play a key role in ion homeostasis and cell volume regulation. In addition, TRP channels are considered universal integrators of sensory information required for taste, vision, hearing, touch, temperature, and the detection of mechanical force. Seminal investigations exploring the molecular mechanisms of phototransduction in Drosophila have demonstrated that TRP channels operate within macromolecular complexes closely associated with the cytoskeleton. More recent evidence shows that mammalian TRP channels similarly connect to the cytoskeleton to affect cytoskeletal organization and cell adhesion via ion-transport-dependent and -independent mechanisms. In this review, we discuss new insights into the interplay between TRP channels and the cytoskeleton and provide recent examples of such interactions in different physiological systems.
KW - Animals
KW - Cytoskeleton/metabolism
KW - Drosophila Proteins/physiology
KW - Drosophila melanogaster/metabolism
KW - Endothelial Cells/metabolism
KW - Hearing Disorders/etiology
KW - Humans
KW - Kidney/physiology
KW - Kidney Diseases/etiology
KW - Models, Biological
KW - Transient Receptor Potential Channels/metabolism
KW - Vision, Ocular/physiology
U2 - 10.1016/j.ejcb.2008.01.009
DO - 10.1016/j.ejcb.2008.01.009
M3 - Review article
C2 - 18342984
SN - 0171-9335
VL - 87
SP - 631
EP - 640
JO - European journal of cell biology
JF - European journal of cell biology
IS - 8-9
ER -