Intestinal regeneration: YAP-tumor suppressor and oncoprotein?

Vivian S.W. Li; Hans Clevers

doi:10.1016/j.cub.2012.12.021

Intestinal regeneration: YAP-tumor suppressor and oncoprotein?

Vivian S.W. Li, Hans Clevers

Onderzoeksoutput: Bijdrage aan tijdschrift › Kort overzicht › peer review

16 Citaten (Scopus)

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The Hippo signaling pathway exerts a growth-suppressive effect by inhibitory phosphorylation of the oncogenic transcription co-activator Yki/YAP. A recent study paradoxically reports that genetic removal of YAP enhances intestinal stem cell expansion and regeneration.

Originele taal-2	Engels
Pagina's (van-tot)	R110-R112
Tijdschrift	Current Biology
Volume	23
Nummer van het tijdschrift	3
DOI's	https://doi.org/10.1016/j.cub.2012.12.021
Status	Gepubliceerd - 4 feb. 2013
Extern gepubliceerd	Ja

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10.1016/j.cub.2012.12.021

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title = "Intestinal regeneration: YAP-tumor suppressor and oncoprotein?",

abstract = "The Hippo signaling pathway exerts a growth-suppressive effect by inhibitory phosphorylation of the oncogenic transcription co-activator Yki/YAP. A recent study paradoxically reports that genetic removal of YAP enhances intestinal stem cell expansion and regeneration.",

author = "Li, \{Vivian S.W.\} and Hans Clevers",

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AU - Clevers, Hans

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N2 - The Hippo signaling pathway exerts a growth-suppressive effect by inhibitory phosphorylation of the oncogenic transcription co-activator Yki/YAP. A recent study paradoxically reports that genetic removal of YAP enhances intestinal stem cell expansion and regeneration.

AB - The Hippo signaling pathway exerts a growth-suppressive effect by inhibitory phosphorylation of the oncogenic transcription co-activator Yki/YAP. A recent study paradoxically reports that genetic removal of YAP enhances intestinal stem cell expansion and regeneration.

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DO - 10.1016/j.cub.2012.12.021

M3 - Short survey

AN - SCOPUS:84873336472

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VL - 23

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JO - Current Biology

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Intestinal regeneration: YAP-tumor suppressor and oncoprotein?

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